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Tdark
NKAIN1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

Protein Summary
Description
NKAIN1 is a member of a family of mammalian proteins with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
virus perturbation
0.64
transcription factor perturbation
0.61
tissue
0.57
histone modification site profile
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.35   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.35   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
LRRC8D
Tbio
Novelty:  0.10536285
p_int:  0.999996667
p_ni:  0.000003333
Data Source:  BioPlex
FZD6
Tbio
Family:  GPCR
Novelty:  0.01425136
p_int:  0.999965288
p_ni:  0.000034559
p_wrong:  1.53e-7
Data Source:  BioPlex
TRPM4
Tchem
Family:  IC
Novelty:  0.00423106
p_int:  0.999958641
p_ni:  0.000040983
p_wrong:  3.77e-7
Data Source:  BioPlex
PARP16
Tchem
Family:  Enzyme
Novelty:  0.09651799
p_int:  0.999936953
p_ni:  0.00005862
p_wrong:  0.000004428
Data Source:  BioPlex
TRPM7
Tchem
Family:  IC
Novelty:  0.00265096
p_int:  0.999898564
p_ni:  0.000101434
p_wrong:  2e-9
Data Source:  BioPlex
FADS1
Tchem
Family:  Enzyme
Novelty:  0.00160193
p_int:  0.999586521
p_ni:  0.000413477
p_wrong:  2e-9
Data Source:  BioPlex
GJA1
Tbio
Novelty:  0.00021332
p_int:  0.999557387
p_ni:  0.000442613
Data Source:  BioPlex
TMEM63B
Tdark
Family:  IC
Novelty:  0.25017412
p_int:  0.999490649
p_ni:  0.00050935
p_wrong:  1e-9
Data Source:  BioPlex
ABCC10
Tbio
Family:  Transporter
Novelty:  0.02281831
p_int:  0.999106704
p_ni:  0.000893107
p_wrong:  1.88e-7
Data Source:  BioPlex
SLC15A4
Tbio
Family:  Transporter
Novelty:  0.01325014
p_int:  0.998834133
p_ni:  0.001120224
p_wrong:  0.000045643
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
64.4
hematocrit
2
2
2
59.6
hip circumference
1
2
2
59
BMI-adjusted hip circumference
1
2
2
57.3
serum urea measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
64.4
hematocrit
2
59.6
hip circumference
2
59
BMI-adjusted hip circumference
2
57.3
serum urea measurement
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium/potassium transporting ATPase interacting 1
VGNC:8081
456696
Macaque
sodium/potassium transporting ATPase interacting 1
704595
Mouse
MGI:1914399
67149
Rat
RGD:1561205
500557
Dog
sodium/potassium transporting ATPase interacting 1
VGNC:43824
611917
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium/potassium transporting ATPase interacting 1
Macaque
sodium/potassium transporting ATPase interacting 1
Mouse
Rat
Dog
sodium/potassium transporting ATPase interacting 1
Publication Statistics
PubMed Score 2.35
PubMed score by year
PubTator Score 2.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title