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Tbio
NIT1
Deaminated glutathione amidase

Protein Summary
Description
Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368007
  • ENSP00000356986
  • ENSG00000158793
  • ENST00000368008
  • ENSP00000356987
  • ENST00000368009
  • ENSP00000356988
  • ENST00000392190
  • ENSP00000376028
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
disease perturbation
0.93
transcription factor perturbation
0.88
histone modification site profile
0.86
cell type or tissue
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.03   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.03   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
GTPBP8
Tdark
Novelty:  4.38933188
p_int:  0.999858587
p_ni:  0.000141412
p_wrong:  1e-9
Data Source:  BioPlex
MRM2
Tbio
Family:  Enzyme
Novelty:  0.06394065
p_int:  0.99983219
p_ni:  0.000167794
p_wrong:  1.6e-8
Data Source:  BioPlex
POLG
Tchem
Family:  Enzyme
Novelty:  0.00172189
p_int:  0.999683718
p_ni:  0.000316281
Score:  0.158
Data Source:  BioPlex,STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.999597823
p_ni:  0.000253208
p_wrong:  0.000148969
Data Source:  BioPlex
ISOC2
Tbio
Family:  Enzyme
Novelty:  0.33841868
p_int:  0.999511666
p_ni:  0.000382261
p_wrong:  0.000106073
Score:  0.249
Data Source:  BioPlex,STRINGDB
ACSF2
Tbio
Family:  Enzyme
Novelty:  0.10280059
p_int:  0.999500602
p_ni:  0.000499398
Score:  0.229
Data Source:  BioPlex,STRINGDB
LARS2
Tbio
Family:  Enzyme
Novelty:  0.00543895
p_int:  0.995132347
p_ni:  0.004867653
Data Source:  BioPlex
SLC25A20
Tbio
Family:  Transporter
Novelty:  0.00503518
p_int:  0.987995977
p_ni:  0.009978504
p_wrong:  0.002025519
Score:  0.196
Data Source:  BioPlex,STRINGDB
NIPSNAP3A
Tdark
Novelty:  0.45687717
p_int:  0.985205462
p_ni:  0.014794538
Data Source:  BioPlex
FDXR
Tbio
Family:  Enzyme
Novelty:  0.00171588
p_int:  0.968859076
p_ni:  0.031140924
Score:  0.218
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
4
93
monocyte percentage of leukocytes
2
2
3
85.2
serum non-albumin protein measurement
1
2
2
84.7
4
2
0
1.1
82.8
leukocyte count
2
2
2
81.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
93
monocyte percentage of leukocytes
3
85.2
serum non-albumin protein measurement
2
84.7
0
1.1
82.8
leukocyte count
2
81.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nitrilase 1
VGNC:1415
745973
Macaque
nitrilase 1
720272
Mouse
MGI:1350916
27045
Rat
RGD:727821
289222
Dog
nitrilase 1
VGNC:53123
478977
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nitrilase 1
Macaque
nitrilase 1
Mouse
Rat
Dog
nitrilase 1
Publication Statistics
PubMed Score 210.03
PubMed score by year
PubTator Score 18.42
PubTator score by year
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Related Publications
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PMID
Year
Title