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Tbio
NIPSNAP2
Protein NipSnap homolog 2

Protein Summary
Description
May act as a positive regulator of L-type calcium channels. This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. The encoded protein is localized to mitochondria and plays a role in oxidative phosphorylation. A pseudogene of this gene is located on the long arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322090
  • ENSP00000313050
  • ENSG00000146729
  • ENST00000446778
  • ENSP00000406855

Symbol
  • GBAS
  • GBAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.61   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.61   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
PRKCZ
Tchem
Family:  Kinase
Novelty:  0.00201366
p_int:  0.990044862
p_ni:  0.009955138
Score:  0.219
Data Source:  BioPlex,STRINGDB
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.964085359
p_ni:  0.035914641
Score:  0.175
Data Source:  BioPlex,STRINGDB
EDDM3B
Tdark
Novelty:  0.12874735
p_int:  0.830474292
p_ni:  0.169525708
Data Source:  BioPlex
IL25
Tbio
Novelty:  0.01620324
p_int:  0.822354953
p_ni:  0.177644699
p_wrong:  3.48e-7
Data Source:  BioPlex
CD44
Tbio
Novelty:  0.00011321
p_int:  0.777313387
p_ni:  0.222686613
Score:  0.183
Data Source:  BioPlex,STRINGDB
DCP2
Tbio
Family:  Enzyme
Novelty:  0.00661786
p_int:  0.764405889
p_ni:  0.235594111
Score:  0.238
Data Source:  BioPlex,STRINGDB
NDUFS1
Tclin
Family:  Enzyme
Novelty:  0.0215624
Score:  0.915
Data Source:  STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
Score:  0.835
Data Source:  STRINGDB
NDUFV1
Tclin
Family:  Enzyme
Novelty:  0.01929835
Score:  0.822
Data Source:  STRINGDB
ANKFY1
Tbio
Novelty:  0.06469475
Score:  0.74
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
3
10
19
97.5
glycine measurement
5
3
4
12.1
97.5
serine measurement
1
1
0
17.3
86.1
blood metabolite measurement
2
1
2
84.8
glomerular filtration rate
4
4
3
5.7
81
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
19
97.5
glycine measurement
4
12.1
97.5
serine measurement
0
17.3
86.1
blood metabolite measurement
2
84.8
glomerular filtration rate
3
5.7
81
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nipsnap homolog 2
VGNC:7383
742505
Macaque
nipsnap homolog 2
715352
Mouse
MGI:1278343
14467
Rat
RGD:1566421
498174
Chicken
glioblastoma amplified sequence
CGNC:1703
417539
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nipsnap homolog 2
Macaque
nipsnap homolog 2
Mouse
Rat
Chicken
glioblastoma amplified sequence
Publication Statistics
PubMed Score 20.61
PubMed score by year
PubTator Score 5.89
PubTator score by year
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Related Publications
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PMID
Year
Title