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Tbio
NIPSNAP1
Protein NipSnap homolog 1

Protein Summary
Description
This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216121
  • ENSP00000216121
  • ENSG00000184117
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
0.94
histone modification site profile
0.84
disease perturbation
0.79
hub protein
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.15   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.15   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
TRPV6
Tchem
Family:  IC
Novelty:  0.00383629
Score:  0.96
Data Source:  STRINGDB
TRPV5
Tchem
Family:  IC
Novelty:  0.0055156
Score:  0.715
Data Source:  STRINGDB
THOC5
Tbio
Novelty:  0.04618391
Score:  0.711
Data Source:  STRINGDB
TAF1B
Tbio
Family:  Enzyme
Novelty:  0.10174314
Score:  0.632
Data Source:  STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
Score:  0.597
Data Source:  STRINGDB
PDIK1L
Tdark
Family:  Kinase
Novelty:  0.4630487
Score:  0.592
Data Source:  STRINGDB
LRRC46
Tdark
Novelty:  1.159245
Score:  0.569
Data Source:  STRINGDB
DOP1A
Tdark
Novelty:  0.040097
Score:  0.543
Data Source:  STRINGDB
TBC1D2B
Tdark
Novelty:  0.52348266
Score:  0.542
Data Source:  STRINGDB
ANKFY1
Tbio
Novelty:  0.06469475
Score:  0.534
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
3
3
81.3
self reported educational attainment
1
1
1
42.1
high density lipoprotein cholesterol measurement
1
1
1
36.4
lifestyle measurement
1
1
1
34.9
apolipoprotein A 1 measurement
1
1
1
30.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
3
81.3
self reported educational attainment
1
42.1
high density lipoprotein cholesterol measurement
1
36.4
lifestyle measurement
1
34.9
apolipoprotein A 1 measurement
1
30.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nipsnap homolog 1
VGNC:5287
458743
Mouse
MGI:1278344
18082
Rat
RGD:1310419
360971
Dog
nipsnap homolog 1
VGNC:43820
611870
Horse
nipsnap homolog 1
VGNC:20742
100064294
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nipsnap homolog 1
Mouse
Rat
Dog
nipsnap homolog 1
Horse
nipsnap homolog 1
Publication Statistics
PubMed Score 11.15
PubMed score by year
PubTator Score 5.05
PubTator score by year
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Related Publications
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PMID
Year
Title