Tbio NINL Ninein-like protein

Protein Summary

Description

Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.

Uniprot Accession IDs

• Q9Y2I6
• A6NJN0
• B3V9H6
• B7Z1V8
• Q5JYP0
• Q8NE38
• Q9NQE3

Gene Name

• NINL

Ensembl ID

• ENST00000278886
• ENSP00000278886
• ENSG00000101004
• ENST00000422516
• ENSP00000410431

Symbol

• KIAA0980
• NLP
• NLP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.84
gene perturbation	0.74
virus perturbation	0.72
cell line	0.66
transcription factor	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.04   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 53   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.04   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (150)

Explore Interacting Targets

1 – 10 of 150

• See Interactions on String-DB

FAM9C

Tdark

Novelty:  0.86727989

p_int:  0.99999999

p_ni:  9e-9

p_wrong:  1e-9

Data Source:  BioPlex

RGS2

Tbio

Novelty:  0.00370571

p_int:  0.999999976

p_ni:  1.7e-8

p_wrong:  7e-9

Score:  0.188

Data Source:  BioPlex,STRINGDB

LRRC39

Tdark

Novelty:  0.70657884

p_int:  0.999999875

p_ni:  1.24e-7

Score:  0.519

Data Source:  BioPlex,STRINGDB

ZNF408

Tbio

Family:  TF

Novelty:  0.10649477

p_int:  0.999999535

p_ni:  4.61e-7

p_wrong:  4e-9

Data Source:  BioPlex

CCDC172

Tdark

Novelty:  4.18978102

p_int:  0.999995778

p_ni:  0.000004222

Score:  0.214

Data Source:  BioPlex,STRINGDB

MRPS34

Tbio

Novelty:  0.29355603

p_int:  0.999989217

p_ni:  0.000010774

p_wrong:  9e-9

Data Source:  BioPlex

NKAP

Tbio

Novelty:  0.04982584

p_int:  0.999694167

p_ni:  0.000295559

p_wrong:  0.000010274

Data Source:  BioPlex

TPM2

Tbio

Novelty:  0.00406572

p_int:  0.849087416

p_ni:  0.136816387

p_wrong:  0.014096198

Data Source:  BioPlex

PLK1

Tchem

Family:  Kinase

Novelty:  0.00062799

Score:  0.978

Data Source:  STRINGDB

TUBG1

Tbio

Novelty:  0.02252882

Score:  0.966

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (19)

Reactome (16)

PathwayCommons (2)

WikiPathways (1)

AURKA Activation by TPX2 (R-HSA-8854518)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AURKA Activation by TPX2	72 targets	R-HSA-8854518
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Centrosome maturation	81 targets	R-HSA-380287

Name	Explore in Pharos	Explore in Source
AURKA Activation by TPX2	72 targets	R-HSA-8854518
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Centrosome maturation	81 targets	R-HSA-380287

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (1)

Components (4)

Processes (4)

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1 – 1 of 1

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
smoking initiation	EFO_0005670	1	1	1		61.4
platelet count	EFO_0004309	1	1	1		39.6
urate measurement	EFO_0004531	1	1	1		35

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
smoking initiation	EFO_0005670	1		61.4
platelet count	EFO_0004309	1		39.6
urate measurement	EFO_0004531	1		35

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Metal-binding
Microtubule
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
platelet count
smoking initiation
urate measurement

MGI Phenotype Find Similar Targets

No Header	No Header
growth/size/body region phenotype
hematopoietic system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ninein like	VGNC:6212	458148
Macaque	ninein like		706257
Mouse	ninein-like	MGI:1925427	78177
Rat	ninein-like	RGD:1306152	311529
Dog	ninein like	VGNC:43813	477006

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ninein like
Macaque	ninein like
Mouse	ninein-like
Rat	ninein-like
Dog	ninein like

Publication Statistics

PubMed Score 143.04

PubMed score by year

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PubTator Score 169.24

PubTator score by year

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Related Publications

Text Mined References (29)

GeneRif Annotations (13)

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10

0 of 0

PMID	Year	Title