Tbio NIN Ninein

Protein Summary

Description

Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8N4C6
• A6NDB8
• B7WPA3
• C9JSB6
• C9JSG2
• C9JXL2
• Q5BKU3
• Q6P0P6
• Q9BWU6
• Q9C012
• Q9C013
• Q9C014
• Q9H5I6
• Q9HAT7
• Q9HBY5
• Q9HCK7
• Q9UH61
• hNinein

Gene Name

• NIN

Ensembl ID

• ENST00000245441
• ENSP00000245441
• ENSG00000100503
• ENST00000324330
• ENSP00000324210
• ENST00000382041
• ENSP00000371472
• ENST00000382043
• ENSP00000371474
• ENST00000530997
• ENSP00000436092

Symbol

• KIAA1565
• SCKL7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.84
cellular component	0.81
microRNA	0.78
transcription factor binding site profile	0.73
virus perturbation	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.01   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.01   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0