Protein Summary
Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
- ENST00000245441
- ENSP00000245441
- ENSG00000100503
- ENST00000324330
- ENSP00000324210
- ENST00000382041
- ENSP00000371472
- ENST00000382043
- ENSP00000371474
- ENST00000530997
- ENSP00000436092
- KIAA1565
- SCKL7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.84 | ||
cellular component | 0.81 | ||
microRNA | 0.78 | ||
transcription factor binding site profile | 0.73 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.7 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 129 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.7 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 129 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (117)
CEP170
Novelty: 0.05342931
p_int: 0.999999783
p_ni: 2.11e-7
p_wrong: 6e-9
Score: 0.974
Data Source: BioPlex,STRINGDB
ARSE
Family: Enzyme
Novelty: 0.00151862
p_int: 0.999995124
p_ni: 0.000002555
p_wrong: 0.000002322
Data Source: BioPlex
ZNF331
Family: TF
Novelty: 0.05976217
p_int: 0.99939045
p_ni: 0.000609538
p_wrong: 1.2e-8
Data Source: BioPlex
COG5
Novelty: 0.04017657
p_int: 0.998931786
p_ni: 0.001068199
p_wrong: 1.5e-8
Score: 0.185
Data Source: BioPlex,STRINGDB
CCDC68
Novelty: 0.1262502
p_int: 0.994489861
p_ni: 0.004741499
p_wrong: 0.00076864
Score: 0.934
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
PathwayCommons (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: panther | PDGF signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
PDGF signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (3)
Components (15)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 5 | 5 | 98.2 | |||||
platelet count | 1 | 2 | 2 | 68.4 | |||||
serum alanine aminotransferase measurement | 1 | 1 | 0 | 6.9 | 52.4 | ||||
balding measurement | 1 | 1 | 1 | 35 | |||||
1 | 1 | 0 | 1.1 | 29 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 5 | 98.2 | |||||
platelet count | 2 | 68.4 | |||||
serum alanine aminotransferase measurement | 0 | 6.9 | 52.4 | ||||
balding measurement | 1 | 35 | |||||
0 | 1.1 | 29 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ninein | VGNC:3375 | 452901 | |||||
Macaque | ninein | 709532 | ||||||
Mouse | MGI:105108 | 18080 | ||||||
Rat | RGD:1306492 | 299117 | ||||||
Rat | RGD:6493757 | 100911256 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ninein | |||||
Macaque | ninein | |||||
Mouse | ||||||
Rat | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 79.70
PubMed score by year
PubTator Score 220.40
PubTator score by year
Related Publications
Text Mined References (45)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
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