Protein Summary
Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions. This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]
- ENST00000216286
- ENSP00000216286
- ENSG00000087303
- NID-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
PubMedID | 0.97 | ||
gene perturbation | 0.91 | ||
kinase perturbation | 0.84 | ||
histone modification site profile | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 62.13 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 142 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 62.13 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 142 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (87)
PILRA
Novelty: 0.05154386
p_int: 0.99999918
p_ni: 8.2e-7
Score: 0.161
Data Source: BioPlex,STRINGDB
LGALS9
Novelty: 0.00381766
p_int: 0.999967004
p_ni: 0.000032785
p_wrong: 2.1e-7
Data Source: BioPlex
ETV6
Family: TF
Novelty: 0.00151718
p_int: 0.999920149
p_ni: 0.000079848
p_wrong: 4e-9
Score: 0.237
Data Source: BioPlex,STRINGDB
LGALS3
Novelty: 0.00032754
p_int: 0.99980156
p_ni: 0.000188322
p_wrong: 0.000010118
Score: 0.185
Data Source: BioPlex,STRINGDB
MATN2
Novelty: 0.08506252
p_int: 0.99924011
p_ni: 0.000759855
p_wrong: 3.5e-8
Score: 0.234
Data Source: BioPlex,STRINGDB
TMEM25
Novelty: 0.35505784
p_int: 0.998891939
p_ni: 0.001108018
p_wrong: 4.3e-8
Data Source: BioPlex
PITRM1
Family: Enzyme
Novelty: 0.08067518
p_int: 0.998834776
p_ni: 0.001164957
p_wrong: 2.67e-7
Data Source: BioPlex
EPHA7
Family: Kinase
Novelty: 0.01065563
p_int: 0.998356155
p_ni: 0.001643769
p_wrong: 7.6e-8
Score: 0.182
Data Source: BioPlex,STRINGDB
DEFA1
Novelty: 0.01027492
p_int: 0.997379827
p_ni: 0.002620121
p_wrong: 5.3e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Extracellular matrix organization | ||||
Reactome | Laminin interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Extracellular matrix organization | ||||
Laminin interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (3)
Components (5)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 2 | 3 | 77 | |||||
waist-hip ratio | 1 | 2 | 2 | 47.5 | |||||
age-related hearing impairment | 1 | 1 | 0 | 6.5 | 46.1 | ||||
body mass index | 1 | 1 | 1 | 44.2 | |||||
triglyceride measurement | 2 | 2 | 2 | 39.4 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 3 | 77 | |||||
waist-hip ratio | 2 | 47.5 | |||||
age-related hearing impairment | 0 | 6.5 | 46.1 | ||||
body mass index | 1 | 44.2 | |||||
triglyceride measurement | 2 | 39.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | nidogen 2 | VGNC:3376 | 452905 | |||||
Macaque | nidogen 2 | 710184 | ||||||
Mouse | MGI:1298229 | 18074 | ||||||
Rat | RGD:1311685 | 302248 | ||||||
Cow | nidogen 2 | VGNC:32074 | 521854 | |||||
Publication Statistics
PubMed Score 62.13
PubMed score by year
PubTator Score 34.99
PubTator score by year
Related Publications
Text Mined References (34)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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