Tbio NID2 Nidogen-2

Protein Summary

Description

Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions. This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q14112
• A8K6I7
• B4DU19
• O43710
• NID-2

Gene Name

• NID2

Ensembl ID

• ENST00000216286
• ENSP00000216286
• ENSG00000087303

Symbol

• NID-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
PubMedID	0.97
gene perturbation	0.91
kinase perturbation	0.84
histone modification site profile	0.72

Protein Classes

PANTHER Classes

Protein / Calcium-binding Protein / Nidogen-2

DTO Classes

Protein / Calcium-binding Protein / Nidogen-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.13   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.13   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (87)

Explore Interacting Targets

1 – 10 of 87

• See Interactions on String-DB

LYG2

Tbio

Family:  Enzyme

Novelty:  0.12091256

p_int:  0.999999806

p_ni:  1.94e-7

Data Source:  BioPlex

PILRA

Tbio

Novelty:  0.05154386

p_int:  0.99999918

p_ni:  8.2e-7

Score:  0.161

Data Source:  BioPlex,STRINGDB

LGALS9

Tchem

Novelty:  0.00381766

p_int:  0.999967004

p_ni:  0.000032785

p_wrong:  2.1e-7

Data Source:  BioPlex

ETV6

Tbio

Family:  TF

Novelty:  0.00151718

p_int:  0.999920149

p_ni:  0.000079848

p_wrong:  4e-9

Score:  0.237

Data Source:  BioPlex,STRINGDB

LGALS3

Tchem

Novelty:  0.00032754

p_int:  0.99980156

p_ni:  0.000188322

p_wrong:  0.000010118

Score:  0.185

Data Source:  BioPlex,STRINGDB

MATN2

Tbio

Novelty:  0.08506252

p_int:  0.99924011

p_ni:  0.000759855

p_wrong:  3.5e-8

Score:  0.234

Data Source:  BioPlex,STRINGDB

TMEM25

Tdark

Novelty:  0.35505784

p_int:  0.998891939

p_ni:  0.001108018

p_wrong:  4.3e-8

Data Source:  BioPlex

PITRM1

Tchem

Family:  Enzyme

Novelty:  0.08067518

p_int:  0.998834776

p_ni:  0.001164957

p_wrong:  2.67e-7

Data Source:  BioPlex

EPHA7

Tchem

Family:  Kinase

Novelty:  0.01065563

p_int:  0.998356155

p_ni:  0.001643769

p_wrong:  7.6e-8

Score:  0.182

Data Source:  BioPlex,STRINGDB

DEFA1

Tbio

Novelty:  0.01027492

p_int:  0.997379827

p_ni:  0.002620121

p_wrong:  5.3e-8

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

Reactome (2)

Extracellular matrix organization (R-HSA-1474244)

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5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Laminin interactions	23 targets	R-HSA-3000157

Name	Explore in Pharos	Explore in Source
Extracellular matrix organization	297 targets	R-HSA-1474244
Laminin interactions	23 targets	R-HSA-3000157

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (3)

Components (5)

Processes (4)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
extracellular matrix structural constituent	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
collagen binding	Traceable Author Statement (TAS)	ProtInc
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	2	2	3		77
waist-hip ratio	EFO_0004343	1	2	2		47.5
age-related hearing impairment	EFO_0005782	1	1	0	6.5	46.1
body mass index	EFO_0004340	1	1	1		44.2
triglyceride measurement	EFO_0004530	2	2	2		39.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	3		77
waist-hip ratio	EFO_0004343	2		47.5
age-related hearing impairment	EFO_0005782	0	6.5	46.1
body mass index	EFO_0004340	1		44.2
triglyceride measurement	EFO_0004530	2		39.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Basement membrane
Calcium
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
age-related hearing impairment
apolipoprotein A 1 measurement
BMI-adjusted waist-hip ratio
body mass index
high density lipoprotein cholesterol measurement
hip circumference
triglyceride measurement
waist-hip ratio
white matter hyperintensity measurement

MGI Phenotype Find Similar Targets

No Header	No Header
immune system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nidogen 2	VGNC:3376	452905
Macaque	nidogen 2		710184
Mouse	nidogen 2	MGI:1298229	18074
Rat	nidogen 2	RGD:1311685	302248
Cow	nidogen 2	VGNC:32074	521854

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nidogen 2
Macaque	nidogen 2
Mouse	nidogen 2
Rat	nidogen 2
Cow	nidogen 2

Publication Statistics

PubMed Score 62.13

PubMed score by year

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PubTator Score 34.99

PubTator score by year

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Related Publications

Text Mined References (34)

GeneRif Annotations (15)

Items per page:

10

0 of 0

PMID	Year	Title