Tdark NHSL1 NHS-like protein 1

Protein Summary

Uniprot Accession IDs

• Q5SYE7
• Q3ZCS5
• Q5SYE8
• Q9P2J0

Gene Name

• NHSL1

Ensembl ID

• ENST00000343505
• ENSP00000344672
• ENSG00000135540
• ENST00000427025
• ENSP00000394546

Symbol

• C6orf63
• KIAA1357
• C6orf63

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.76
microRNA	0.73
small molecule perturbation	0.66
PubMedID	0.61
cell line	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.46   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 67   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.46   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (30)

Explore Interacting Targets

1 – 10 of 30

• See Interactions on String-DB

NCKAP1

Tbio

Novelty:  0.03486454

p_int:  0.999999994

p_ni:  6e-9

p_wrong:  1e-9

Score:  0.299

Data Source:  BioPlex,STRINGDB

BRK1

Tbio

Novelty:  0.02289534

p_int:  0.999999933

p_ni:  3.9e-8

p_wrong:  2.9e-8

Score:  0.444

Data Source:  BioPlex,STRINGDB

ABI2

Tbio

Novelty:  0.02324355

p_int:  0.999999901

p_ni:  9.9e-8

Score:  0.754

Data Source:  BioPlex,STRINGDB

NCK1

Tbio

Novelty:  0.00352084

p_int:  0.99999966

p_ni:  3.4e-7

Data Source:  BioPlex

NCK2

Tbio

Novelty:  0.02220251

p_int:  0.999998659

p_ni:  8e-9

p_wrong:  0.000001333

Score:  0.539

Data Source:  BioPlex,STRINGDB

AMZ1

Tdark

Family:  Enzyme

Novelty:  0.246305

p_int:  0.999971321

p_ni:  0.000028679

Score:  0.827

Data Source:  BioPlex,STRINGDB

NHSL2

Tdark

Novelty:  4.36275023

Score:  0.828

Data Source:  STRINGDB

C10orf53

Tdark

Novelty:  4.63758308

Score:  0.678

Data Source:  STRINGDB

PPIL4

Tdark

Family:  Enzyme

Novelty:  0.3737992

Score:  0.581

Data Source:  STRINGDB

FGD6

Tbio

Novelty:  0.07213159

Score:  0.561

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Processes (1)

Find Similar Targets

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
cell differentiation	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
corneal topography	EFO_0004345	2	1	2		72.9
cortical surface area measurement	EFO_0010736	1	1	0	19.2	64.9
type II diabetes mellitus	EFO_0001360	1	1	1		46.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
corneal topography	EFO_0004345	2		72.9
cortical surface area measurement	EFO_0010736	0	19.2	64.9
type II diabetes mellitus	EFO_0001360	1		46.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
corneal topography
cortical surface area measurement
type II diabetes mellitus

MGI Phenotype Find Similar Targets

No Header	No Header
endocrine/exocrine gland phenotype
reproductive system phenotype
respiratory system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NHS like 1	VGNC:3590	472137
Macaque	NHS like 1		703448
Mouse	NHS-like 1	MGI:106390	215819
Rat	NHS-like 1	RGD:1308124	308631
Dog	NHS like 1	VGNC:43805	100856148

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NHS like 1
Macaque	NHS like 1
Mouse	NHS-like 1
Rat	NHS-like 1
Dog	NHS like 1

Publication Statistics

PubMed Score 4.46

PubMed score by year

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PubTator Score 1.69

PubTator score by year

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Related Publications

Text Mined References (4)

Items per page:

10

0 of 0

PMID	Year	Title