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Tdark
NHSL1
NHS-like protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343505
  • ENSP00000344672
  • ENSG00000135540
  • ENST00000427025
  • ENSP00000394546

Symbol
  • C6orf63
  • KIAA1357
  • C6orf63
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
microRNA
0.73
small molecule perturbation
0.66
PubMedID
0.61
cell line
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.46   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.46   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
NCKAP1
Tbio
Novelty:  0.03486454
p_int:  0.999999994
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.299
Data Source:  BioPlex,STRINGDB
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999999933
p_ni:  3.9e-8
p_wrong:  2.9e-8
Score:  0.444
Data Source:  BioPlex,STRINGDB
ABI2
Tbio
Novelty:  0.02324355
p_int:  0.999999901
p_ni:  9.9e-8
Score:  0.754
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.99999966
p_ni:  3.4e-7
Data Source:  BioPlex
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999998659
p_ni:  8e-9
p_wrong:  0.000001333
Score:  0.539
Data Source:  BioPlex,STRINGDB
AMZ1
Tdark
Family:  Enzyme
Novelty:  0.246305
p_int:  0.999971321
p_ni:  0.000028679
Score:  0.827
Data Source:  BioPlex,STRINGDB
NHSL2
Tdark
Novelty:  4.36275023
Score:  0.828
Data Source:  STRINGDB
C10orf53
Tdark
Novelty:  4.63758308
Score:  0.678
Data Source:  STRINGDB
PPIL4
Tdark
Family:  Enzyme
Novelty:  0.3737992
Score:  0.581
Data Source:  STRINGDB
FGD6
Tbio
Novelty:  0.07213159
Score:  0.561
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
2
1
2
72.9
cortical surface area measurement
1
1
0
19.2
64.9
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
2
72.9
cortical surface area measurement
0
19.2
64.9
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NHS like 1
VGNC:3590
472137
Macaque
NHS like 1
703448
Mouse
MGI:106390
215819
Rat
RGD:1308124
308631
Dog
NHS like 1
VGNC:43805
100856148
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NHS like 1
Macaque
NHS like 1
Mouse
Rat
Dog
NHS like 1
Publication Statistics
PubMed Score 4.46
PubMed score by year
PubTator Score 1.69
PubTator score by year
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Related Publications
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PMID
Year
Title