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Tbio
NHP2
H/ACA ribonucleoprotein complex subunit 2

Protein Summary
Description
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nuc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274606
  • ENSP00000274606
  • ENSG00000145912

Symbol
  • NOLA2
  • DKCB2
  • NHP2P
  • NOLA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
protein complex
0.96
transcription factor perturbation
0.94
kinase perturbation
0.76
hub protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.6   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.6   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (563)
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
p_int:  0.877755994
p_ni:  0.122244006
Score:  0.332
Data Source:  BioPlex,STRINGDB
GAR1
Tbio
Novelty:  0.26091307
Score:  0.999
Data Source:  STRINGDB
DKC1
Tbio
Novelty:  0.00352181
Score:  0.999
Data Source:  STRINGDB
NOP10
Tbio
Novelty:  0.0188462
Score:  0.999
Data Source:  STRINGDB
NOP58
Tbio
Novelty:  0.02148045
Score:  0.999
Data Source:  STRINGDB
NAF1
Tbio
Novelty:  2.99493689
Score:  0.998
Data Source:  STRINGDB
NOP56
Tbio
Novelty:  0.01256937
Score:  0.998
Data Source:  STRINGDB
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
Score:  0.997
Data Source:  STRINGDB
RRP9
Tbio
Novelty:  0.07232317
Score:  0.991
Data Source:  STRINGDB
TERT
Tchem
Family:  Enzyme
Novelty:  0.00024411
Score:  0.988
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Chromosome Maintenance
Reactome
Extension of Telomeres
Reactome
Metabolism of RNA
Reactome
Telomere Extension By Telomerase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Chromosome Maintenance
Extension of Telomeres
Metabolism of RNA
Telomere Extension By Telomerase
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
83.9
reticulocyte measurement
2
1
2
73.7
reticulocyte count
1
1
1
70
platelet count
2
2
2
58.2
mean platelet volume
2
1
2
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
83.9
reticulocyte measurement
2
73.7
reticulocyte count
1
70
platelet count
2
58.2
mean platelet volume
2
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1098547
52530
Dog
NHP2 ribonucleoprotein
VGNC:43803
474644
Horse
NHP2 ribonucleoprotein
VGNC:20734
100058092
Cow
NHP2 ribonucleoprotein
VGNC:32070
520891
Opossum
NHP2 ribonucleoprotein
100027968
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
NHP2 ribonucleoprotein
Horse
NHP2 ribonucleoprotein
Cow
NHP2 ribonucleoprotein
Opossum
NHP2 ribonucleoprotein
Publication Statistics
PubMed Score 57.60
PubMed score by year
PubTator Score 19.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title