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Tbio
NHLH2
Helix-loop-helix protein 2

Protein Summary
Description
May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320238
  • ENSP00000322087
  • ENSG00000177551
  • ENST00000369506
  • ENSP00000358519

Symbol
  • BHLHA34
  • HEN2
  • KIAA0490
  • HEN2
  • NSCL2
  • bHLHa34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.71
cell type or tissue
0.68
biological process
0.66
gene perturbation
0.65
phenotype
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.52   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.52   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
p_int:  0.999998322
p_ni:  0.000001678
Score:  0.464
Data Source:  BioPlex,STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
p_int:  0.999994939
p_ni:  0.000005061
Score:  0.388
Data Source:  BioPlex,STRINGDB
CCDC71L
Tdark
Novelty:  1.22334925
p_int:  0.999993452
p_ni:  0.000001743
p_wrong:  0.000004804
Data Source:  BioPlex
TCF12
Tbio
Family:  TF
Novelty:  0.00381424
p_int:  0.999987435
p_ni:  0.00001256
p_wrong:  6e-9
Score:  0.484
Data Source:  BioPlex,STRINGDB
ARFGEF1
Tbio
Novelty:  0.16148196
p_int:  0.999977724
p_ni:  0.000022276
Data Source:  BioPlex
ARFGEF2
Tbio
Novelty:  0.05568966
p_int:  0.999947178
p_ni:  0.000052822
Data Source:  BioPlex
AP3B1
Tbio
Novelty:  0.03117931
p_int:  0.998125048
p_ni:  0.001874952
Data Source:  BioPlex
CUEDC1
Tbio
Novelty:  0.14401061
p_int:  0.995708027
p_ni:  0.004291973
Data Source:  BioPlex
GFAP
Tbio
Novelty:  0.00020932
p_int:  0.992110994
p_ni:  0.007884704
p_wrong:  0.000004302
Data Source:  BioPlex
GTF2I
Tbio
Family:  TF
Novelty:  0.00703345
p_int:  0.951792566
p_ni:  0.048207434
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Prader-Willi and Angelman Syndrome
WikiPathways
Prader-Willi and Angelman Syndrome
WikiPathways
Prader-Willi and Angelman Syndrome
WikiPathways
Prader-Willi and Angelman Syndrome
WikiPathways
Prader-Willi and Angelman Syndrome
Name
Explore in Pharos
Explore in Source
Prader-Willi and Angelman Syndrome
Prader-Willi and Angelman Syndrome
Prader-Willi and Angelman Syndrome
Prader-Willi and Angelman Syndrome
Prader-Willi and Angelman Syndrome
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
20
78
2
2
0
1.1
77.6
left atrial function
2
1
2
59.5
heart function measurement
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
20
78
0
1.1
77.6
left atrial function
2
59.5
heart function measurement
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97324
18072
Rat
RGD:1308294
295327
Dog
nescient helix-loop-helix 2
VGNC:43799
483135
Cow
nescient helix-loop-helix 2
VGNC:32066
525699
Pig
nescient helix-loop-helix 2
100152544
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
nescient helix-loop-helix 2
Cow
nescient helix-loop-helix 2
Pig
nescient helix-loop-helix 2
Publication Statistics
PubMed Score 25.52
PubMed score by year
PubTator Score 27.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title