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Tbio
NGRN
Neugrin

Protein Summary
Description
Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379095
  • ENSP00000368389
  • ENSG00000182768

Symbol
  • FI58G
  • DSC92
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
co-expressed gene
0.82
cell type or tissue
0.74
transcription factor binding site profile
0.7
histone modification site profile
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.47   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.47   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
BANP
Tbio
Novelty:  0.02145545
p_int:  0.999967463
p_ni:  0.000032537
Data Source:  BioPlex
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.999286107
p_ni:  0.000713893
Data Source:  BioPlex
HNRNPA1
Tchem
Novelty:  0.0020871
p_int:  0.999108043
p_ni:  0.000891956
p_wrong:  1e-9
Data Source:  BioPlex
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.997573815
p_ni:  0.002426185
Data Source:  BioPlex
RBM42
Tdark
Novelty:  0.37655036
p_int:  0.997200545
p_ni:  0.002799455
Data Source:  BioPlex
CIRBP
Tbio
Novelty:  0.00439066
p_int:  0.990720733
p_ni:  0.009279267
Data Source:  BioPlex
MRPL4
Tbio
Novelty:  0.27290276
p_int:  0.986951431
p_ni:  0.013048518
p_wrong:  5.1e-8
Data Source:  BioPlex
RBMX
Tbio
Novelty:  0.01705784
p_int:  0.985657655
p_ni:  0.014342345
Data Source:  BioPlex
MRPL39
Tbio
Novelty:  0.14346457
p_int:  0.978545665
p_ni:  0.021454334
p_wrong:  2e-9
Data Source:  BioPlex
CDX1
Tbio
Family:  TF
Novelty:  0.00815821
p_int:  0.966784949
p_ni:  0.033215051
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.3
92.3
alkaline phosphatase measurement
2
2
1
7.3
81
serum gamma-glutamyl transferase measurement
3
2
3
67.1
frontal fibrosing alopecia
1
1
0
1.5
55.4
multiple sclerosis
1
1
0
1.1
22.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
92.3
alkaline phosphatase measurement
1
7.3
81
serum gamma-glutamyl transferase measurement
3
67.1
frontal fibrosing alopecia
0
1.5
55.4
multiple sclerosis
0
1.1
22.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neugrin, neurite outgrowth associated
VGNC:7763
745536
Macaque
neugrin, neurite outgrowth associated-like
701554
Mouse
MGI:1933212
83485
Rat
RGD:1583734
499191
Dog
neugrin, neurite outgrowth associated
100684886
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neugrin, neurite outgrowth associated
Macaque
neugrin, neurite outgrowth associated-like
Mouse
Rat
Dog
neugrin, neurite outgrowth associated
Publication Statistics
PubMed Score 22.47
PubMed score by year
PubTator Score 5.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title