You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Protein Summary
Description
Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding di ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280700
  • ENSP00000280700
  • ENSG00000151092
  • ENST00000396649
  • ENSP00000379886
  • ENST00000417874
  • ENSP00000389888
  • ENST00000428257
  • ENSP00000387430

Symbol
  • PNG1
  • CDDG
  • PNG1
  • CDG1V
  • PNGase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
histone modification site profile
0.87
disease perturbation
0.74
protein domain
0.73
transcription factor binding site profile
0.63


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.08   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.08   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
NAGPA
Tbio
Family:  Enzyme
Novelty:  0.03136768
p_int:  0.994181736
p_ni:  0.005818264
Score:  0.221
Data Source:  BioPlex,STRINGDB
B4GALT4
Tbio
Family:  Enzyme
Novelty:  0.11226614
p_int:  0.988384015
p_ni:  0.011615985
Score:  0.532
Data Source:  BioPlex,STRINGDB
SGSH
Tbio
Family:  Enzyme
Novelty:  0.00670111
p_int:  0.959269562
p_ni:  0.040730438
Data Source:  BioPlex
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.908291088
p_ni:  0.091708912
Data Source:  BioPlex
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.875747945
p_ni:  0.124252055
Data Source:  BioPlex
LINGO1
Tbio
Novelty:  0.00778085
p_int:  0.851028242
p_ni:  0.148971758
Score:  0.187
Data Source:  BioPlex,STRINGDB
RAD23B
Tbio
Novelty:  0.00672104
p_int:  0.850811284
p_ni:  0.149188716
Score:  0.993
Data Source:  BioPlex,STRINGDB
VCP
Tchem
Family:  Enzyme
Novelty:  0.00103317
Score:  0.976
Data Source:  STRINGDB
AMFR
Tbio
Family:  Enzyme
Novelty:  0.00533547
Score:  0.966
Data Source:  STRINGDB
DERL1
Tbio
Novelty:  0.01382722
Score:  0.963
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
5.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-glycanase 1
VGNC:2443
460233
Macaque
N-glycanase 1
700842
Mouse
MGI:1913276
59007
Rat
RGD:1308518
361014
Dog
N-glycanase 1
VGNC:43796
100682555
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-glycanase 1
Macaque
N-glycanase 1
Mouse
Rat
Dog
N-glycanase 1
Publication Statistics
PubMed Score 130.08
PubMed score by year
PubTator Score 180.87
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title