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Tclin
NGFR
Tumor necrosis factor receptor superfamily member 16

Protein Summary
Description
Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Ju ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000172229
  • ENSP00000172229
  • ENSG00000064300
  • ENST00000504201
  • ENSP00000421731

Symbol
  • TNFRSF16
  • CD271
  • p75NTR
  • TNFRSF16
  • p75(NTR)
  • Gp80-LNGFR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
PubMedID
0.87
ligand (protein)
0.85
protein complex
0.74
biological term
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1450.42   (req: < 5)
Gene RIFs: 211   (req: <= 3)
Antibodies: 1398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1450.42   (req: >= 5)
Gene RIFs: 211   (req: > 3)
Antibodies: 1398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (266)
NGF
Tchem
Novelty:  0.00008139
Score:  0.998
Data Source:  Reactome,STRINGDB
ARHGDIA
Tchem
Novelty:  0.001991
Score:  0.997
Data Source:  Reactome,STRINGDB
BDNF
Tchem
Novelty:  0.00006891
Score:  0.996
Data Source:  STRINGDB
NTF3
Tbio
Novelty:  0.00089023
Score:  0.996
Data Source:  STRINGDB
NTRK1
Tclin
Family:  Kinase
Novelty:  0.00033453
Score:  0.994
Data Source:  STRINGDB
NTF4
Tbio
Novelty:  0.00192875
Score:  0.993
Data Source:  STRINGDB
NDN
Tbio
Novelty:  0.0045625
Score:  0.993
Data Source:  STRINGDB
NTRK2
Tclin
Family:  Kinase
Novelty:  0.00054534
Score:  0.992
Data Source:  STRINGDB
SORT1
Tchem
Novelty:  0.00319862
Score:  0.989
Data Source:  STRINGDB
RIPK2
Tchem
Family:  Kinase
Novelty:  0.00574043
Score:  0.988
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (66)
Axonal growth inhibition (RHOA activation) (R-HSA-193634)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axonal growth inhibition (RHOA activation)
Reactome
Axonal growth stimulation
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Ceramide signalling
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Axonal growth inhibition (RHOA activation)
Axonal growth stimulation
Cell death signalling via NRAGE, NRIF and NADE
Ceramide signalling
Death Receptor Signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Genetic Interaction (IGI)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
2
81
mean corpuscular volume
1
1
1
33.1
appendicular lean mass
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
81
mean corpuscular volume
1
33.1
appendicular lean mass
1
8.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nerve growth factor receptor
VGNC:9474
455206
Macaque
nerve growth factor receptor
574304
Mouse
MGI:97323
18053
Rat
RGD:3177
24596
Dog
nerve growth factor receptor [Source:HGNC Symbol;Acc:HGNC:7809]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nerve growth factor receptor
Macaque
nerve growth factor receptor
Mouse
Rat
Dog
nerve growth factor receptor [Source:HGNC Symbol;Acc:HGNC:7809]
Publication Statistics
PubMed Score 1450.42
PubMed score by year
PubTator Score 761.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title