Tchem NGF Beta-nerve growth factor

Protein Summary

Description

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P01138
• A1A4E5
• Q6FHA0
• Q96P60
• Q9P2Q8
• Q9UKL8
• Beta-NGF

Gene Name

• NGF

Ensembl ID

• ENST00000369512
• ENSP00000358525
• ENSG00000134259

Symbol

• NGFB
• NGFB
• HSAN5
• Beta-NGF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	0.99
chemical	0.99
gene perturbation	0.93
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Neurotrophic Factor / Beta-nerve Growth Factor

DTO Classes

Protein / Signaling / Growth Factor / Neurotrophic Factor / Beta-nerve Growth Factor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13981.66   (req: < 5)

Gene RIFs: 319   (req: <= 3)

Antibodies: 912   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13981.66   (req: >= 5)

Gene RIFs: 319   (req: > 3)

Antibodies: 912   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0