Protein Summary
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
- ENST00000264051
- ENSP00000264051
- ENSG00000066248
- ENST00000373552
- ENSP00000362653
- ENST00000409079
- ENSP00000387033
- EPHEXIN
- ARHGEF27
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.99 | ||
transcription factor | 0.62 | ||
biological process | 0.6 | ||
PubMedID | 0.6 | ||
gene perturbation | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.89 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 109 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.89 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 109 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (109)
SLC12A8
Family: Transporter
Novelty: 0.06012072
p_int: 0.999982989
p_ni: 0.00001701
p_wrong: 1e-9
Score: 0.485
Data Source: BioPlex,STRINGDB
PRKCI
Family: Kinase
Novelty: 0.0076377
p_int: 0.991970848
p_ni: 0.008028852
p_wrong: 3e-7
Score: 0.244
Data Source: BioPlex,STRINGDB
MRS2
Novelty: 0.00264753
p_int: 0.925863125
p_ni: 0.07413687
p_wrong: 5e-9
Score: 0.185
Data Source: BioPlex,STRINGDB
ACTR1B
Novelty: 0.10014723
p_int: 0.898463278
p_ni: 0.101536722
Score: 0.363
Data Source: BioPlex,STRINGDB
ACTR10
Novelty: 0.11388846
p_int: 0.882231017
p_ni: 0.117768976
p_wrong: 7e-9
Score: 0.674
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (68)
Reactome (14)
KEGG (1)
PathwayCommons (4)
WikiPathways (49)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Reactome | Death Receptor Signalling | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Cell death signalling via NRAGE, NRIF and NADE | ||||
Death Receptor Signalling | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
bilirubin measurement | 2 | 7 | 12 | 94.9 | |||||
mathematical ability | 4 | 4 | 7 | 93.2 | |||||
heel bone mineral density | 3 | 2 | 3 | 89.4 | |||||
6 | 2 | 1 | 1.1 | 75.7 | |||||
self reported educational attainment | 2 | 2 | 2 | 71.3 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
bilirubin measurement | 12 | 94.9 | |||||
mathematical ability | 7 | 93.2 | |||||
heel bone mineral density | 3 | 89.4 | |||||
1 | 1.1 | 75.7 | |||||
self reported educational attainment | 2 | 71.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | neuronal guanine nucleotide exchange factor | VGNC:2709 | 460020 | |||||
Macaque | neuronal guanine nucleotide exchange factor | 713917 | ||||||
Mouse | MGI:1858414 | 53972 | ||||||
Rat | RGD:1309055 | 246217 | ||||||
Dog | neuronal guanine nucleotide exchange factor | VGNC:43795 | 486165 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | neuronal guanine nucleotide exchange factor | |||||
Macaque | neuronal guanine nucleotide exchange factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | neuronal guanine nucleotide exchange factor | |||||
Publication Statistics
PubMed Score 18.89
PubMed score by year
PubTator Score 8.37
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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