Tbio NGEF Ephexin-1

Protein Summary

Description

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

Uniprot Accession IDs

• Q8N5V2
• B4DMB8
• B9A045
• E9PC42
• Q53QQ4
• Q53ST7
• Q6GMQ5
• Q9NQD6

Gene Name

• NGEF

Ensembl ID

• ENST00000264051
• ENSP00000264051
• ENSG00000066248
• ENST00000373552
• ENSP00000362653
• ENST00000409079
• ENSP00000387033

Symbol

• EPHEXIN
• ARHGEF27

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
transcription factor	0.62
biological process	0.6
PubMedID	0.6
gene perturbation	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.04   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.04   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0