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Tbio
NFKBIL1
NF-kappa-B inhibitor-like protein 1

Protein Summary
Description
Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376148
  • ENSP00000365318
  • ENSG00000204498
  • ENST00000383500
  • ENSP00000372992
  • ENSG00000206440
  • ENST00000400279
  • ENSP00000383137
  • ENST00000400285
  • ENSP00000383142
  • ENST00000414391
  • ENSP00000414084
  • ENSG00000234530
  • ENST00000419122
  • ENSP00000394486
  • ENST00000419623
  • ENSP00000414206
  • ENSG00000236346
  • ENST00000421396
  • ENSP00000399871
  • ENSG00000235125
  • ENST00000424652
  • ENSP00000395544
  • ENST00000428467
  • ENSP00000407809
  • ENST00000430501
  • ENSP00000404901
  • ENSG00000236196
  • ENST00000430961
  • ENSP00000411174
  • ENST00000432160
  • ENSP00000411611
  • ENSG00000227565
  • ENST00000434332
  • ENSP00000413952
  • ENST00000442947
  • ENSP00000396656
  • ENST00000451911
  • ENSP00000413643
  • ENST00000453377
  • ENSP00000395977
  • ENST00000455376
  • ENSP00000408426
  • ENST00000456607
  • ENSP00000401830

Symbol
  • IKBL
  • IKBL
  • NFKBIL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
biological process
0.78
small molecule perturbation
0.68
disease
0.67
phenotype
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.37   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.37   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0