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Tbio
NFKBIB
NF-kappa-B inhibitor beta

Protein Summary
Description
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313582
  • ENSP00000312988
  • ENSG00000104825
  • ENST00000572515
  • ENSP00000459728
  • ENST00000634647
  • ENSP00000489145
  • ENSG00000282905
  • ENST00000635517
  • ENSP00000489138

Symbol
  • IKBB
  • TRIP9
  • IKBB
  • TRIP9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
histone modification site profile
0.87
transcription factor perturbation
0.84
chemical
0.8
biological process
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.58   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 728   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.58   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 728   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
REL
Tbio
Family:  TF
Novelty:  0.00038265
p_int:  1
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  1
Score:  0.606
Data Source:  BioPlex,STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
p_int:  0.999999997
p_ni:  3e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
MCC
Tbio
Novelty:  0.10374312
p_int:  0.999999994
p_ni:  6e-9
Score:  0.295
Data Source:  BioPlex,STRINGDB
NFKB1
Tclin
Family:  TF
Novelty:  0.00198195
p_int:  0.999999796
p_ni:  2.01e-7
p_wrong:  3e-9
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
BIRC7
Tchem
Novelty:  0.00420245
p_int:  0.999999609
p_ni:  3.66e-7
p_wrong:  2.5e-8
Score:  0.254
Data Source:  BioPlex,STRINGDB
NFKB2
Tchem
Family:  TF
Novelty:  0.00366074
p_int:  0.999996888
p_ni:  0.000003112
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
NFKBIA
Tchem
Novelty:  0.00022873
p_int:  0.999996845
p_ni:  0.000003138
p_wrong:  1.7e-8
Score:  0.977
Data Source:  BioPlex,STRINGDB
POLR1E
Tbio
Family:  Enzyme
Novelty:  0.09991103
p_int:  0.997805855
p_ni:  0.002194109
p_wrong:  3.6e-8
Score:  0.265
Data Source:  BioPlex,STRINGDB
TBP
Tbio
Novelty:  0.00034941
p_int:  0.918184482
p_ni:  0.081815518
Score:  0.28
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (73)
Activation of NF-kappaB in B cells (R-HSA-1169091)

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Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
Cytokine Signaling in Immune system
Cytosolic sensors of pathogen-associated DNA
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
SIR2-like protein 2 measurement
1
1
1
81.1
SIR2-like protein 2 measurement
1
1
1
81.1
serum gamma-glutamyl transferase measurement
1
1
1
50.6
serum gamma-glutamyl transferase measurement
1
1
1
50.6
diastolic blood pressure
1
1
1
40.7
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
SIR2-like protein 2 measurement
1
81.1
SIR2-like protein 2 measurement
1
81.1
serum gamma-glutamyl transferase measurement
1
50.6
serum gamma-glutamyl transferase measurement
1
50.6
diastolic blood pressure
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NFKB inhibitor beta
VGNC:8295
456014
Macaque
NFKB inhibitor beta
694844
Mouse
MGI:104752
18036
Rat
RGD:621887
81525
Dog
NFKB inhibitor beta
VGNC:43783
484519
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NFKB inhibitor beta
Macaque
NFKB inhibitor beta
Mouse
Rat
Dog
NFKB inhibitor beta
Publication Statistics
PubMed Score 151.58
PubMed score by year
PubTator Score 103.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title