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Tchem
NFKBIA
NF-kappa-B inhibitor alpha

Protein Summary
Description
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216797
  • ENSP00000216797
  • ENSG00000100906

Symbol
  • IKBA
  • MAD3
  • NFKBI
  • IKBA
  • MAD-3
  • NFKBI
  • EDAID2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
disease perturbation
1
hub protein
1
kinase
1


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3907.71   (req: < 5)
Gene RIFs: 227   (req: <= 3)
Antibodies: 1668   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3907.71   (req: >= 5)
Gene RIFs: 227   (req: > 3)
Antibodies: 1668   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (388)
REL
Tbio
Family:  TF
Novelty:  0.00038265
p_int:  1
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
RELB
Tbio
Family:  TF
Novelty:  0.00216805
p_int:  1
Score:  0.952
Data Source:  BioPlex,STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
p_int:  0.999999997
p_ni:  3e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
NFKB2
Tchem
Family:  TF
Novelty:  0.00366074
p_int:  0.999999966
p_ni:  3.4e-8
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
NFKB1
Tclin
Family:  TF
Novelty:  0.00198195
p_int:  0.999999949
p_ni:  5e-8
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ANKRD27
Tbio
Novelty:  0.02843267
p_int:  0.999999933
p_ni:  6.7e-8
Score:  0.329
Data Source:  BioPlex,STRINGDB
NFKBIB
Tbio
Novelty:  0.00517222
p_int:  0.999996845
p_ni:  0.000003138
p_wrong:  1.7e-8
Score:  0.977
Data Source:  BioPlex,STRINGDB
OGDHL
Tbio
Family:  Enzyme
Novelty:  0.05079572
p_int:  0.99998144
p_ni:  0.000018521
p_wrong:  3.9e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
p_int:  0.999655555
p_ni:  0.000344442
p_wrong:  3e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
TBC1D24
Tbio
Novelty:  0.0161631
p_int:  0.999191717
p_ni:  0.000771686
p_wrong:  0.000036597
Score:  0.191
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (12)
Explore Nearest Tclin Targets
1 – 5 of 5
Pathways (175)
Activation of NF-kappaB in B cells (R-HSA-1169091)

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Items per page:
1 – 5 of 54
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Cytokine Signaling in Immune system
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
1
3
82
eosinophil count
3
2
3
81.4
eosinophil percentage of leukocytes
2
2
2
77.3
leukocyte count
1
1
1
63.7
BMI-adjusted hip circumference
2
2
3
47.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
82
eosinophil count
3
81.4
eosinophil percentage of leukocytes
2
77.3
leukocyte count
1
63.7
BMI-adjusted hip circumference
3
47.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NFKB inhibitor alpha
VGNC:8204
467426
Macaque
NFKB inhibitor alpha
695335
Mouse
MGI:104741
18035
Rat
RGD:3171
25493
Dog
NFKB inhibitor alpha
VGNC:43782
480291
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NFKB inhibitor alpha
Macaque
NFKB inhibitor alpha
Mouse
Rat
Dog
NFKB inhibitor alpha
Publication Statistics
PubMed Score 3907.71
PubMed score by year
PubTator Score 2145.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title