Tchem NFKBIA NF-kappa-B inhibitor alpha

Protein Summary

Description

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• P25963
• B2R8L6

Gene Name

• NFKBIA

Ensembl ID

• ENST00000216797
• ENSP00000216797
• ENSG00000100906

Symbol

• IKBA
• MAD3
• NFKBI
• IKBA
• MAD-3
• NFKBI
• EDAID2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	1
disease perturbation	1
hub protein	1
kinase	1

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3907.71   (req: < 5)

Gene RIFs: 227   (req: <= 3)

Antibodies: 1668   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3907.71   (req: >= 5)

Gene RIFs: 227   (req: > 3)

Antibodies: 1668   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (4)

Explore Active Ligands

1 – 4 of 4

CHEMBL272552

NFKBIATchem

pIC50 : 6.89

CHEMBL271669

NFKBIATchem

pEC50 : 6.3

CHEMBL4071045

NFKBIATchem

pKd : 6.13

2-methyl-5-nitro-N-(quinolin-8-yl)benzenesulfonamide

NFKBIATchem

pEC50 : 6

Protein-Protein Interactions (388)

Explore Interacting Targets

1 – 10 of 388

• See Interactions on String-DB

REL

Tbio

Family:  TF

Novelty:  0.00038265

p_int:  1

Score:  0.997

Data Source:  BioPlex,Reactome,STRINGDB

RELB

Tbio

Family:  TF

Novelty:  0.00216805

p_int:  1

Score:  0.952

Data Source:  BioPlex,STRINGDB

RELA

Tchem

Family:  TF

Novelty:  0.0007137

p_int:  0.999999997

p_ni:  3e-9

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

NFKB2

Tchem

Family:  TF

Novelty:  0.00366074

p_int:  0.999999966

p_ni:  3.4e-8

Score:  0.994

Data Source:  BioPlex,Reactome,STRINGDB

NFKB1

Tclin

Family:  TF

Novelty:  0.00198195

p_int:  0.999999949

p_ni:  5e-8

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

ANKRD27

Tbio

Novelty:  0.02843267

p_int:  0.999999933

p_ni:  6.7e-8

Score:  0.329

Data Source:  BioPlex,STRINGDB

NFKBIB

Tbio

Novelty:  0.00517222

p_int:  0.999996845

p_ni:  0.000003138

p_wrong:  1.7e-8

Score:  0.977

Data Source:  BioPlex,STRINGDB

OGDHL

Tbio

Family:  Enzyme

Novelty:  0.05079572

p_int:  0.99998144

p_ni:  0.000018521

p_wrong:  3.9e-8

Score:  0.219

Data Source:  BioPlex,STRINGDB

CHUK

Tchem

Family:  Kinase

Novelty:  0.00151532

p_int:  0.999655555

p_ni:  0.000344442

p_wrong:  3e-9

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

TBC1D24

Tbio

Novelty:  0.0161631

p_int:  0.999191717

p_ni:  0.000771686

p_wrong:  0.000036597

Score:  0.191

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (12)

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Upstream (5)

Downstream (7)

1 – 5 of 5

PIK3CA

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  30

1: Chronic myeloid leukemia

2: Relaxin signaling pathway

3: T cell receptor signaling pathway

4: B cell receptor signaling pathway

more:  26 more common pathways

PIK3CD

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  30

1: Chronic myeloid leukemia

2: Relaxin signaling pathway

3: T cell receptor signaling pathway

4: B cell receptor signaling pathway

more:  26 more common pathways

CD3E

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  9

1: T cell receptor signaling pathway

2: PD-L1 expression and PD-1 checkpoint pathway in cancer

3: Human T-cell leukemia virus 1 infection

4: Chagas disease (American trypanosomiasis)

more:  5 more common pathways

CD3D

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  9

1: T cell receptor signaling pathway

2: PD-L1 expression and PD-1 checkpoint pathway in cancer

3: Human T-cell leukemia virus 1 infection

4: Chagas disease (American trypanosomiasis)

more:  5 more common pathways

CD3G

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  9

1: T cell receptor signaling pathway

2: PD-L1 expression and PD-1 checkpoint pathway in cancer

3: Human T-cell leukemia virus 1 infection

4: Chagas disease (American trypanosomiasis)

more:  5 more common pathways

Pathways (175)

Reactome (54)

KEGG (43)

PathwayCommons (36)

WikiPathways (42)

Activation of NF-kappaB in B cells (R-HSA-1169091)

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Items per page:

5

1 – 5 of 54

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of NF-kappaB in B cells	68 targets	R-HSA-1169091
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Reactome	CLEC7A (Dectin-1) signaling	101 targets	R-HSA-5607764
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Name	Explore in Pharos	Explore in Source
Activation of NF-kappaB in B cells	68 targets	R-HSA-1169091
Adaptive Immune System	894 targets	R-HSA-1280218
C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
CLEC7A (Dectin-1) signaling	101 targets	R-HSA-5607764
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (43)

Functions (6)

Components (7)

Processes (30)

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10

1 – 6 of 6

GO Term	Evidence	Assigned by
NF-kappaB binding	Inferred from Direct Assay (IDA)	MGI
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
nuclear localization sequence binding	Inferred from Physical Interaction (IPI)	UniProtKB
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	UniProtKB
transcription factor binding	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (16)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	3	1	3		82
eosinophil count	EFO_0004842	3	2	3		81.4
eosinophil percentage of leukocytes	EFO_0007991	2	2	2		77.3
leukocyte count	EFO_0004308	1	1	1		63.7
BMI-adjusted hip circumference	EFO_0008039	2	2	3		47.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	3		82
eosinophil count	EFO_0004842	3		81.4
eosinophil percentage of leukocytes	EFO_0007991	2		77.3
leukocyte count	EFO_0004308	1		63.7
BMI-adjusted hip circumference	EFO_0008039	3		47.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
ANK repeat
Complete proteome
Cytoplasm
Disease mutation
Ectodermal dysplasia
Host-virus interaction
Hydroxylation
Isopeptide bond
Nucleus

GWAS Trait Find Similar Targets

No Header	No Header
allergic rhinitis
asthma
BMI-adjusted hip circumference
creatine kinase measurement
Eczema
eosinophil count
eosinophil percentage of granulocytes
eosinophil percentage of leukocytes
leukocyte count
lymphocyte count

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NFKB inhibitor alpha	VGNC:8204	467426
Macaque	NFKB inhibitor alpha		695335
Mouse	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	MGI:104741	18035
Rat	NFKB inhibitor alpha	RGD:3171	25493
Dog	NFKB inhibitor alpha	VGNC:43782	480291

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NFKB inhibitor alpha
Macaque	NFKB inhibitor alpha
Mouse	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Rat	NFKB inhibitor alpha
Dog	NFKB inhibitor alpha

Publication Statistics

PubMed Score 3907.71

PubMed score by year

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PubTator Score 2145.36

PubTator score by year

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Related Publications

Text Mined References (396)

GeneRif Annotations (227)

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PMID	Year	Title