NFKBIA
NF-kappa-B inhibitor alpha
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
disease perturbation | 1 | ||
hub protein | 1 | ||
kinase | 1 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of NF-kappaB in B cells | ||||
Reactome | Adaptive Immune System | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | CLEC7A (Dectin-1) signaling | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of NF-kappaB in B cells | ||||
Adaptive Immune System | ||||
C-type lectin receptors (CLRs) | ||||
CLEC7A (Dectin-1) signaling | ||||
Cytokine Signaling in Immune system | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 1 | 3 | 82 | |||||
eosinophil count | 3 | 2 | 3 | 81.4 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 2 | 77.3 | |||||
leukocyte count | 1 | 1 | 1 | 63.7 | |||||
BMI-adjusted hip circumference | 2 | 2 | 3 | 47.4 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 82 | |||||
eosinophil count | 3 | 81.4 | |||||
eosinophil percentage of leukocytes | 2 | 77.3 | |||||
leukocyte count | 1 | 63.7 | |||||
BMI-adjusted hip circumference | 3 | 47.4 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | NFKB inhibitor alpha | VGNC:8204 | 467426 | |||||
Macaque | NFKB inhibitor alpha | 695335 | ||||||
Mouse | MGI:104741 | 18035 | ||||||
Rat | RGD:3171 | 25493 | ||||||
Dog | NFKB inhibitor alpha | VGNC:43782 | 480291 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | NFKB inhibitor alpha | |||||
Macaque | NFKB inhibitor alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | NFKB inhibitor alpha | |||||
PMID | Year | Title |
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