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Tclin
NFKB1
Nuclear factor NF-kappa-B p105 subunit

Protein Summary
Description
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226574
  • ENSP00000226574
  • ENSG00000109320
  • ENST00000394820
  • ENSP00000378297
  • ENST00000505458
  • ENSP00000424790
  • ENST00000600343
  • ENSP00000469340

Symbol
  • p50
  • KBF1
  • p105
  • EBP-1
  • CVID12
  • NF-kB1
  • NFKB-p50
  • NFkappaB
  • NF-kappaB
  • NFKB-p105
  • NF-kappa-B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
protein domain
1
molecular function
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 529.51   (req: < 5)
Gene RIFs: 2433   (req: <= 3)
Antibodies: 2189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 529.51   (req: >= 5)
Gene RIFs: 2433   (req: > 3)
Antibodies: 2189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1