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Tbio
NFIL3
Nuclear factor interleukin-3-regulated protein

Protein Summary
Description
Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (AT ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297689
  • ENSP00000297689
  • ENSG00000165030

Symbol
  • E4BP4
  • IL3BP1
  • E4BP4
  • IL3BP1
  • NFIL3A
  • NF-IL3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.99
disease perturbation
0.96
PubMedID
0.91
transcription factor binding site profile
0.91


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.33   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 345   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.33   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 345   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
COP1
Tbio
Family:  Enzyme
Novelty:  0.10908534
p_int:  0.997020649
p_ni:  0.002979347
p_wrong:  4e-9
Score:  0.652
Data Source:  BioPlex,STRINGDB
STK40
Tbio
Family:  Kinase
Novelty:  0.10461675
p_int:  0.987134607
p_ni:  0.012863469
p_wrong:  0.000001924
Score:  0.718
Data Source:  BioPlex,STRINGDB
CREB1
Tbio
Family:  TF
Novelty:  0.00018059
p_int:  0.898958695
p_ni:  0.101041303
p_wrong:  2e-9
Score:  0.722
Data Source:  BioPlex,STRINGDB
ATF1
Tchem
Family:  TF
Novelty:  0.01450941
p_int:  0.79893018
p_ni:  0.001270687
p_wrong:  0.199799133
Score:  0.577
Data Source:  BioPlex,STRINGDB
BHLHE41
Tbio
Family:  TF
Novelty:  0.01015053
Score:  0.987
Data Source:  Reactome,STRINGDB
PER2
Tchem
Novelty:  0.00165834
Score:  0.986
Data Source:  STRINGDB
ARNTL
Tbio
Family:  TF
Novelty:  0.00102829
Score:  0.893
Data Source:  STRINGDB
NPAS2
Tbio
Family:  TF
Novelty:  0.00728451
Score:  0.879
Data Source:  STRINGDB
BHLHE40
Tbio
Family:  TF
Novelty:  0.01175662
Score:  0.873
Data Source:  STRINGDB
CRY2
Tbio
Novelty:  0.00156961
Score:  0.844
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
4
4
84.8
1
1
0
2.2
71.3
bilirubin measurement
4
2
4
70.6
body mass index
2
2
2
49.6
sum of eosinophil and basophil counts
1
1
1
46.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
84.8
0
2.2
71.3
bilirubin measurement
4
70.6
body mass index
2
49.6
sum of eosinophil and basophil counts
1
46.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear factor, interleukin 3 regulated
VGNC:4801
742792
Macaque
nuclear factor, interleukin 3 regulated
704757
Mouse
MGI:109495
18030
Rat
RGD:620972
114519
Dog
nuclear factor, interleukin 3 regulated
VGNC:43778
100855456
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear factor, interleukin 3 regulated
Macaque
nuclear factor, interleukin 3 regulated
Mouse
Rat
Dog
nuclear factor, interleukin 3 regulated
Publication Statistics
PubMed Score 147.33
PubMed score by year
PubTator Score 49.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title