NFIC
Nuclear factor 1 C-type
Protein Summary
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
- ENST00000341919
- ENSP00000342194
- ENSG00000141905
- ENST00000395111
- ENSP00000378543
- ENST00000443272
- ENSP00000396843
- ENST00000586919
- ENSP00000465177
- ENST00000589123
- ENSP00000465655
- ENST00000590282
- ENSP00000466647
- NFI
- CTF
- NFI
- CTF5
- NF-I
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.97 | ||
ligand (protein) perturbation | 0.83 | ||
interacting protein | 0.81 | ||
molecular function | 0.81 | ||
transcription factor binding site profile | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 269.38 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 270 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 269.38 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 270 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0