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Tbio
NFIA
Nuclear factor 1 A-type

Protein Summary
Description
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371187
  • ENSP00000360229
  • ENSG00000162599
  • ENST00000371189
  • ENSP00000360231
  • ENST00000403491
  • ENSP00000384523
  • ENST00000407417
  • ENSP00000384680

Symbol
  • KIAA1439
  • CTF
  • NF1-A
  • NFI-A
  • NFI-L
  • BRMUTD
  • NF-I/A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.96
transcription factor
0.96
kinase perturbation
0.88
PubMedID
0.87
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.98   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.98   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
NFIB
Tbio
Family:  TF
Novelty:  0.00608636
p_int:  0.999999292
p_wrong:  7.08e-7
Score:  0.793
Data Source:  BioPlex,STRINGDB
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
Score:  0.91
Data Source:  STRINGDB
POLR3G
Tbio
Family:  Enzyme
Novelty:  0.04923071
Score:  0.907
Data Source:  STRINGDB
CRCP
Tbio
Family:  Enzyme
Novelty:  0.01111812
Score:  0.903
Data Source:  STRINGDB
POLR2H
Tbio
Family:  Enzyme
Novelty:  0.04008409
Score:  0.9
Data Source:  STRINGDB
P0DPB5
Tbio
Novelty:  0.01598347
Score:  0.9
Data Source:  STRINGDB
POLR2L
Tbio
Family:  Enzyme
Novelty:  0.03847579
Score:  0.9
Data Source:  STRINGDB
POLR3K
Tbio
Family:  Enzyme
Novelty:  0.07105011
Score:  0.9
Data Source:  STRINGDB
POLR2F
Tbio
Family:  Enzyme
Novelty:  0.03787683
Score:  0.9
Data Source:  STRINGDB
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Reactome
RNA Polymerase III Transcription
Reactome
RNA Polymerase III Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Termination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
4
10
95.6
electrocardiography
2
2
109
89.2
heel bone mineral density
2
4
4
73.7
risk-taking behaviour
2
2
2
72.1
QRS duration
1
1
1
69.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
10
95.6
electrocardiography
109
89.2
heel bone mineral density
4
73.7
risk-taking behaviour
2
72.1
QRS duration
1
69.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear factor I A
VGNC:10004
741619
Macaque
nuclear factor I A
694022
Mouse
MGI:108056
18027
Rat
RGD:3170
25492
Dog
nuclear factor I A
VGNC:43775
479552
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear factor I A
Macaque
nuclear factor I A
Mouse
Rat
Dog
nuclear factor I A
Publication Statistics
PubMed Score 142.98
PubMed score by year
PubTator Score 49.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title