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Tbio
NFE2L3
Nuclear factor erythroid 2-related factor 3

Protein Summary
Description
Activates erythroid-specific, globin gene expression. This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000056233
  • ENSP00000056233
  • ENSG00000050344

Symbol
  • NRF3
  • NRF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
virus perturbation
0.96
molecular function
0.86
transcription factor perturbation
0.74
gene perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.02   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.02   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
MAFF
Tbio
Family:  TF
Novelty:  0.01974936
p_int:  0.999996865
p_ni:  1.55e-7
p_wrong:  0.00000298
Score:  0.791
Data Source:  BioPlex,STRINGDB
MAFK
Tbio
Family:  TF
Novelty:  0.01735942
p_int:  0.999993696
p_ni:  1e-8
p_wrong:  0.000006294
Score:  0.842
Data Source:  BioPlex,STRINGDB
MAFG
Tbio
Family:  TF
Novelty:  0.01605125
p_int:  0.999938338
p_ni:  1.49e-7
p_wrong:  0.000061513
Score:  0.837
Data Source:  BioPlex,STRINGDB
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.998472776
p_ni:  2.9e-8
p_wrong:  0.001527195
Data Source:  BioPlex
HCFC2
Tbio
Novelty:  0.12260416
p_int:  0.934895788
p_ni:  0.065104212
Score:  0.532
Data Source:  BioPlex,STRINGDB
HCFC1
Tbio
Novelty:  0.00440762
p_int:  0.868693603
p_ni:  0.131306397
Score:  0.813
Data Source:  BioPlex,STRINGDB
NPRL3
Tbio
Family:  Enzyme
Novelty:  0.0110744
Score:  0.748
Data Source:  STRINGDB
OSBPL6
Tbio
Novelty:  0.25692861
Score:  0.693
Data Source:  STRINGDB
BACH2
Tbio
Family:  TF
Novelty:  0.00932069
Score:  0.68
Data Source:  STRINGDB
OSBPL3
Tbio
Novelty:  0.06106368
Score:  0.673
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
1
1
30.2
BMI-adjusted waist-hip ratio
1
1
1
28.1
lymphocyte count
1
1
1
11.9
BMI-adjusted waist circumference
1
1
1
4.3
monocyte percentage of leukocytes
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
30.2
BMI-adjusted waist-hip ratio
1
28.1
lymphocyte count
1
11.9
BMI-adjusted waist circumference
1
4.3
monocyte percentage of leukocytes
1
3.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear factor, erythroid 2 like 3
VGNC:8702
463298
Macaque
nuclear factor, erythroid 2 like 3
702171
Mouse
MGI:1339958
18025
Rat
RGD:1307730
312331
Dog
nuclear factor, erythroid 2 like 3
VGNC:43774
482364
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear factor, erythroid 2 like 3
Macaque
nuclear factor, erythroid 2 like 3
Mouse
Rat
Dog
nuclear factor, erythroid 2 like 3
Publication Statistics
PubMed Score 33.02
PubMed score by year
PubTator Score 12.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title