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Tchem
NFE2L2
Nuclear factor erythroid 2-related factor 2

Protein Summary
Description
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress and the regulation of cellular redox conditions. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397062
  • ENSP00000380252
  • ENSG00000116044
  • ENST00000397063
  • ENSP00000380253
  • ENST00000446151
  • ENSP00000411575
  • ENST00000464747
  • ENSP00000467401

Symbol
  • NRF2
  • NRF2
  • HEBP1
  • IMDDHH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
transcription factor binding site profile
0.99
phenotype
0.98
biological process
0.97
kinase perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3530.21   (req: < 5)
Gene RIFs: 1021   (req: <= 3)
Antibodies: 761   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3530.21   (req: >= 5)
Gene RIFs: 1021   (req: > 3)
Antibodies: 761   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 83
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0