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Tchem
NFE2
Transcription factor NF-E2 45 kDa subunit

Protein Summary
Description
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312156
  • ENSP00000312436
  • ENSG00000123405
  • ENST00000435572
  • ENSP00000397185
  • ENST00000540264
  • ENSP00000439120
  • ENST00000553070
  • ENSP00000447558

Symbol
  • p45
  • NF-E2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
biological process
0.88
histone modification site profile
0.71
transcription factor
0.66
virus perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.93   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.93   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (86)
MAFG
Tbio
Family:  TF
Novelty:  0.01605125
Score:  0.991
Data Source:  Reactome,STRINGDB
MAFK
Tbio
Family:  TF
Novelty:  0.01735942
Score:  0.988
Data Source:  Reactome,STRINGDB
MAFF
Tbio
Family:  TF
Novelty:  0.01974936
Score:  0.985
Data Source:  Reactome,STRINGDB
HBG1
Tbio
Novelty:  0.00384136
Score:  0.957
Data Source:  STRINGDB
HBG2
Tbio
Novelty:  0.01145628
Score:  0.951
Data Source:  STRINGDB
MAF
Tbio
Family:  TF
Novelty:  0.00040887
Score:  0.95
Data Source:  STRINGDB
HBE1
Tbio
Novelty:  0.00125958
Score:  0.942
Data Source:  STRINGDB
HBB
Tbio
Novelty:  0.00049683
Score:  0.941
Data Source:  STRINGDB
RUNX1
Tbio
Family:  TF
Novelty:  0.0085181
Score:  0.926
Data Source:  STRINGDB
HBD
Tbio
Novelty:  0.00203187
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Hemostasis
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Gene expression (Transcription)
Generic Transcription Pathway
Hemostasis
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
6
9
99.5
platelet count
5
5
6
8.7
98.4
red blood cell distribution width
4
2
6
95.6
mean corpuscular volume
1
2
2
94.4
reticulocyte measurement
2
2
2
88
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
99.5
platelet count
6
8.7
98.4
red blood cell distribution width
6
95.6
mean corpuscular volume
2
94.4
reticulocyte measurement
2
88
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear factor, erythroid 2
VGNC:5503
748141
Macaque
nuclear factor, erythroid 2
705061
Mouse
MGI:97308
18022
Rat
RGD:1306888
366998
Dog
nuclear factor, erythroid 2
VGNC:43771
486495
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear factor, erythroid 2
Macaque
nuclear factor, erythroid 2
Mouse
Rat
Dog
nuclear factor, erythroid 2
Publication Statistics
PubMed Score 273.93
PubMed score by year
PubTator Score 241.52
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title