Tbio NFAT5 Nuclear factor of activated T-cells 5

Protein Summary

Description

Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O94916
• A2RRB4
• A6H8V5
• E9PHR7
• O95693
• Q7LA65
• Q969Q8
• Q96QH3
• Q9UN18
• NF-AT5

Gene Name

• NFAT5

Ensembl ID

• ENST00000349945
• ENSP00000338806
• ENSG00000102908
• ENST00000354436
• ENSP00000346420
• ENST00000393742
• ENSP00000377343
• ENST00000426654
• ENSP00000413126
• ENST00000566899
• ENSP00000455628
• ENST00000567239
• ENSP00000457593
• ENST00000627621
• ENSP00000486610

Symbol

• KIAA0827
• TONEBP
• NFATZ
• OREBP
• NF-AT5
• NFATL1
• TONEBP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.97
transcription factor perturbation	0.96
protein domain	0.92
co-expressed gene	0.89
microRNA	0.8

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Nuclear Factor Of Activated T-cells 5

Protein / ... / Rel Homology Transcription Factor / Nuclear Factor Of Activated T-cells 5

DTO Classes

Protein / Transcription Factor / Immunoglobulin Fold Transcription Factor / Rel Homology Transcription Factor / Nuclear Factor Of Activated T-cells 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.05   (req: < 5)

Gene RIFs: 113   (req: <= 3)

Antibodies: 264   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.05   (req: >= 5)

Gene RIFs: 113   (req: > 3)

Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0