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Tbio
NFAT5
Nuclear factor of activated T-cells 5

Protein Summary
Description
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349945
  • ENSP00000338806
  • ENSG00000102908
  • ENST00000354436
  • ENSP00000346420
  • ENST00000393742
  • ENSP00000377343
  • ENST00000426654
  • ENSP00000413126
  • ENST00000566899
  • ENSP00000455628
  • ENST00000567239
  • ENSP00000457593
  • ENST00000627621
  • ENSP00000486610

Symbol
  • KIAA0827
  • TONEBP
  • NFATZ
  • OREBP
  • NF-AT5
  • NFATL1
  • TONEBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
transcription factor perturbation
0.96
protein domain
0.92
co-expressed gene
0.89
microRNA
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.05   (req: < 5)
Gene RIFs: 113   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.05   (req: >= 5)
Gene RIFs: 113   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0