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Tbio
NFAM1
NFAT activation molecule 1

Protein Summary
Description
May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking. The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329021
  • ENSP00000333680
  • ENSG00000235568

Symbol
  • CNAIP
  • CNAIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
biological process
0.64
tissue
0.56
virus perturbation
0.55
cell type or tissue
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.99   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.99   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
HSPA14
Tbio
Novelty:  0.01714625
p_int:  0.998758739
p_ni:  0.001236278
p_wrong:  0.000004983
Score:  0.538
Data Source:  BioPlex,STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
Score:  0.925
Data Source:  STRINGDB
FPR1
Tchem
Family:  GPCR
Novelty:  0.00256884
Score:  0.918
Data Source:  STRINGDB
RAB44
Tdark
Family:  Enzyme
Novelty:  0.16987153
Score:  0.911
Data Source:  STRINGDB
CD68
Tbio
Novelty:  0.00017859
Score:  0.907
Data Source:  STRINGDB
ATP8A1
Tbio
Family:  Transporter
Novelty:  0.02003643
Score:  0.907
Data Source:  STRINGDB
VNN1
Tchem
Family:  Enzyme
Novelty:  0.0144646
Score:  0.906
Data Source:  STRINGDB
LRMP
Tbio
Novelty:  0.03886763
Score:  0.906
Data Source:  STRINGDB
CEACAM8
Tbio
Novelty:  0.00370138
Score:  0.904
Data Source:  STRINGDB
ACPP
Tchem
Family:  Enzyme
Novelty:  0.00364265
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
65.3
cognitive function measurement
3
2
3
63.3
self reported educational attainment
1
1
1
51.4
intelligence
1
1
0
5.9
31.4
chronotype measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
65.3
cognitive function measurement
3
63.3
self reported educational attainment
1
51.4
intelligence
0
5.9
31.4
chronotype measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NFAT activating protein with ITAM motif 1
710294
Mouse
MGI:1921289
74039
Rat
RGD:1308316
362966
Dog
NFAT activating protein with ITAM motif 1
VGNC:43763
609583
Horse
NFAT activating protein with ITAM motif 1
VGNC:20700
100071003
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NFAT activating protein with ITAM motif 1
Mouse
Rat
Dog
NFAT activating protein with ITAM motif 1
Horse
NFAT activating protein with ITAM motif 1
Publication Statistics
PubMed Score 6.99
PubMed score by year
PubTator Score 3.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title