Protein Summary
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene ...more
- ENST00000334961
- ENSP00000335652
- ENSG00000186575
- ENST00000338641
- ENSP00000344666
- ENST00000353887
- ENSP00000340626
- ENST00000361166
- ENSP00000354529
- ENST00000361452
- ENSP00000354897
- ENST00000361676
- ENSP00000355183
- ENST00000397789
- ENSP00000380891
- ENST00000403435
- ENSP00000384029
- ENST00000403999
- ENSP00000384797
- ENST00000413209
- ENSP00000409921
- ENST00000432151
- ENSP00000395885
- SCH
- ACN
- SCH
- BANF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
kinase perturbation | 0.95 | ||
biological process | 0.94 | ||
biological term | 0.91 | ||
cellular component | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2003.94 (req: < 5)
Gene RIFs: 194 (req: <= 3)
Antibodies: 600 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2003.94 (req: >= 5)
Gene RIFs: 194 (req: > 3)
Antibodies: 600 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (145)
PPFIA1
Novelty: 0.01904029
p_int: 0.999999974
p_ni: 2.6e-8
Score: 0.206
Data Source: BioPlex,STRINGDB
TSPYL4
Novelty: 0.4538252
p_int: 0.999576803
p_ni: 0.000422264
p_wrong: 9.32e-7
Score: 0.228
Data Source: BioPlex,STRINGDB
RNF166
Novelty: 0.71460884
p_int: 0.999555445
p_ni: 0.000444555
Score: 0.343
Data Source: BioPlex,STRINGDB
AMOTL1
Novelty: 0.03842225
p_int: 0.999059884
p_ni: 0.000940116
Score: 0.918
Data Source: BioPlex,STRINGDB
CCNL2
Novelty: 0.03667817
p_int: 0.995547343
p_ni: 0.004397645
p_wrong: 0.000055012
Score: 0.181
Data Source: BioPlex,STRINGDB
PDCL
Novelty: 0.00317454
p_int: 0.980176947
p_ni: 0.019823053
Score: 0.212
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (29)
Reactome (8)
KEGG (3)
PathwayCommons (1)
WikiPathways (17)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases activate PAKs | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Immune System | ||||
Innate Immune System | ||||
RHO GTPase Effectors | ||||
RHO GTPases activate PAKs | ||||
Viral Interactions (0)
Gene Ontology Terms (45)
Functions (1)
Components (18)
Processes (26)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
serum non-albumin protein measurement | 1 | 2 | 2 | 71.7 | |||||
glomerular filtration rate | 1 | 1 | 1 | 63.4 | |||||
self reported educational attainment | 1 | 1 | 1 | 55.2 | |||||
lymphocyte count | 1 | 1 | 1 | 50.6 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 46.9 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
serum non-albumin protein measurement | 2 | 71.7 | |||||
glomerular filtration rate | 1 | 63.4 | |||||
self reported educational attainment | 1 | 55.2 | |||||
lymphocyte count | 1 | 50.6 | |||||
high density lipoprotein cholesterol measurement | 1 | 46.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | neurofibromin 2 | VGNC:12905 | 458744 | |||||
Macaque | neurofibromin 2 | 714945 | ||||||
Mouse | MGI:97307 | 18016 | ||||||
Rat | RGD:3169 | 25744 | ||||||
Dog | neurofibromin 2 | VGNC:43762 | 477535 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | neurofibromin 2 | |||||
Macaque | neurofibromin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | neurofibromin 2 | |||||
Publication Statistics
PubMed Score 2003.94
PubMed score by year
PubTator Score 1656.67
PubTator score by year
Related Publications
Text Mined References (263)
GeneRif Annotations (194)
Items per page:
0 of 0
PMID | Year | Title |
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