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Tbio
NF2
Merlin

Protein Summary
Description
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334961
  • ENSP00000335652
  • ENSG00000186575
  • ENST00000338641
  • ENSP00000344666
  • ENST00000353887
  • ENSP00000340626
  • ENST00000361166
  • ENSP00000354529
  • ENST00000361452
  • ENSP00000354897
  • ENST00000361676
  • ENSP00000355183
  • ENST00000397789
  • ENSP00000380891
  • ENST00000403435
  • ENSP00000384029
  • ENST00000403999
  • ENSP00000384797
  • ENST00000413209
  • ENSP00000409921
  • ENST00000432151
  • ENSP00000395885

Symbol
  • SCH
  • ACN
  • SCH
  • BANF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.95
biological process
0.94
biological term
0.91
cellular component
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2317.6   (req: < 5)
Gene RIFs: 194   (req: <= 3)
Antibodies: 600   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2317.6   (req: >= 5)
Gene RIFs: 194   (req: > 3)
Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0