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Tbio
NEXMIF
Neurite extension and migration factor

Protein Summary
Description
Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1). An inversion on the X chromosome which disrupts this gene and a G-protein coupled purinergic receptor gene located in the pseudoautosomal region of the X chromosome has been linked to X linked cognitive disability.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000055682
  • ENSP00000055682
  • ENSG00000050030
  • ENST00000616200
  • ENSP00000480284

Symbol
  • KIAA2022
  • XPN
  • MRX98
  • KIDLIA
  • KIAA2022
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.75   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.75   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
P2RY8
Tbio
Family:  GPCR
Novelty:  0.05574297
Score:  0.81
Data Source:  STRINGDB
POLD2
Tbio
Family:  Enzyme
Novelty:  0.05932998
Score:  0.743
Data Source:  STRINGDB
SPIN3
Tchem
Novelty:  0.16670763
Score:  0.722
Data Source:  STRINGDB
ARHGEF9
Tbio
Novelty:  0.01577146
Score:  0.708
Data Source:  STRINGDB
GRIPAP1
Tbio
Novelty:  0.09814766
Score:  0.706
Data Source:  STRINGDB
RLIM
Tbio
Family:  Enzyme
Novelty:  0.02267745
Score:  0.673
Data Source:  STRINGDB
AMER1
Tbio
Novelty:  0.00951499
Score:  0.665
Data Source:  STRINGDB
FOXR2
Tbio
Family:  TF
Novelty:  0.06548862
Score:  0.65
Data Source:  STRINGDB
POLD3
Tbio
Family:  Enzyme
Novelty:  0.02646621
Score:  0.639
Data Source:  STRINGDB
CLCN5
Tbio
Family:  IC
Novelty:  0.00419772
Score:  0.638
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
49.5
mean reticulocyte volume
1
1
1
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
49.5
mean reticulocyte volume
1
4
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neurite extension and migration factor
703920
Mouse
MGI:2148050
245555
Rat
RGD:1561931
302396
Dog
neurite extension and migration factor
VGNC:43759
100856163
Horse
neurite extension and migration factor
VGNC:20696
100059184
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neurite extension and migration factor
Mouse
Rat
Dog
neurite extension and migration factor
Horse
neurite extension and migration factor
Publication Statistics
PubMed Score 36.75
PubMed score by year
PubTator Score 14.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title