Tbio NEUROG3 Neurogenin-3

Protein Summary

Description

Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q9Y4Z2
• Q5VVI0
• Q6DJX6
• Q9BY24
• NGN-3

Gene Name

• NEUROG3

Ensembl ID

• ENST00000242462
• ENSP00000242462
• ENSG00000122859

Symbol

• ATOH5
• BHLHA7
• NGN3
• ngn3
• Atoh5
• NGN-3
• Math4B
• bHLHa7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
biological process	0.84
PubMedID	0.63
cell type or tissue	0.59
tissue	0.51

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Neurogenin-3

Protein / Nucleic Acid Binding / Nuclease / Neurogenin-3

DTO Classes

Protein / Enzyme / Nuclease / Neurogenin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.41   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 522   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.41   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 522   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (159)

Explore Interacting Targets

1 – 10 of 159

• See Interactions on String-DB

TCF3

Tbio

Family:  TF

Novelty:  0.00112675

p_int:  0.999999935

p_ni:  6.5e-8

Score:  0.561

Data Source:  BioPlex,STRINGDB

TCF4

Tbio

Family:  TF

Novelty:  0.0019718

p_int:  0.999999926

p_ni:  7.4e-8

Score:  0.666

Data Source:  BioPlex,STRINGDB

TCF12

Tbio

Family:  TF

Novelty:  0.00381424

p_int:  0.999999611

p_ni:  3.89e-7

Score:  0.584

Data Source:  BioPlex,STRINGDB

TEP1

Tbio

Family:  Enzyme

Novelty:  0.01254647

p_int:  0.99999858

p_ni:  0.00000136

p_wrong:  6e-8

Score:  0.203

Data Source:  BioPlex,STRINGDB

DCAF4

Tbio

Novelty:  0.24190895

p_int:  0.999992496

p_ni:  0.000007504

Data Source:  BioPlex

ARID3B

Tbio

Family:  TF

Novelty:  0.0691591

p_int:  0.999991526

p_ni:  0.000008474

Score:  0.17

Data Source:  BioPlex,STRINGDB

RMDN2

Tbio

Novelty:  0.10425524

p_int:  0.999990226

p_ni:  0.000009167

p_wrong:  6.08e-7

Score:  0.263

Data Source:  BioPlex,STRINGDB

HES6

Tbio

Family:  TF

Novelty:  0.01546524

p_int:  0.999970018

p_ni:  2e-9

p_wrong:  0.00002998

Score:  0.41

Data Source:  BioPlex,STRINGDB

ZNF100

Tdark

Family:  TF

Novelty:  0.74439926

p_int:  0.999945787

p_ni:  0.000054175

p_wrong:  3.9e-8

Score:  0.197

Data Source:  BioPlex,STRINGDB

YY1AP1

Tbio

Novelty:  0.06862573

p_int:  0.999906062

p_ni:  0.000093935

p_wrong:  4e-9

Score:  0.519

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (4)

KEGG (1)

PathwayCommons (1)

Developmental Biology (R-HSA-1266738)

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Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Regulation of beta-cell development	42 targets	R-HSA-186712
Reactome	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	5 targets	R-HSA-210746
Reactome	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	16 targets	R-HSA-210744

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Regulation of beta-cell development	42 targets	R-HSA-186712
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	5 targets	R-HSA-210746
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	16 targets	R-HSA-210744

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (7)

Components (2)

Processes (14)

Find Similar Targets

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
chromatin DNA binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
transcription coactivator activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
protein dimerization activity	Inferred from Electronic Annotation (IEA)	InterPro
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
venous thromboembolism	EFO_0004286	4	1	1	1.3	84.9
reticulocyte measurement	EFO_0010700	3	2	3		81.3
reticulocyte count	EFO_0007986	2	2	2		81
HbA1c measurement	EFO_0004541	1	2	2		74
type II diabetes mellitus	EFO_0001360	6	2	3	1.1	70.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
venous thromboembolism	EFO_0004286	1	1.3	84.9
reticulocyte measurement	EFO_0010700	3		81.3
reticulocyte count	EFO_0007986	2		81
HbA1c measurement	EFO_0004541	2		74
type II diabetes mellitus	EFO_0001360	3	1.1	70.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Activator
Complete proteome
Developmental protein
Differentiation
Disease mutation
DNA-binding
Neurogenesis
Nucleus
Reference proteome
Transcription

GWAS Trait Find Similar Targets

No Header	No Header
body height
HbA1c measurement
neutrophil count
reticulocyte count
reticulocyte measurement
type II diabetes mellitus
venous thromboembolism

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
cellular phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	neurogenin 3	VGNC:12387	748874
Macaque	neurogenin 3		711583
Mouse	neurogenin 3	MGI:893591	11925
Rat	neurogenin 3	RGD:631350	60329
Dog	neurogenin 3	VGNC:43758	489022

Species	Name	OMA	EggNOG	Inparanoid
Chimp	neurogenin 3
Macaque	neurogenin 3
Mouse	neurogenin 3
Rat	neurogenin 3
Dog	neurogenin 3

Publication Statistics

PubMed Score 337.41

PubMed score by year

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PubTator Score 150.46

PubTator score by year

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Related Publications

Text Mined References (49)

GeneRif Annotations (34)

Items per page:

10

0 of 0

PMID	Year	Title