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Tbio
NEUROG3
Neurogenin-3

Protein Summary
Description
Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242462
  • ENSP00000242462
  • ENSG00000122859

Symbol
  • ATOH5
  • BHLHA7
  • NGN3
  • ngn3
  • Atoh5
  • NGN-3
  • Math4B
  • bHLHa7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
biological process
0.84
PubMedID
0.63
cell type or tissue
0.59
tissue
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.41   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 522   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.41   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 522   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (159)
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
p_int:  0.999999935
p_ni:  6.5e-8
Score:  0.561
Data Source:  BioPlex,STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
p_int:  0.999999926
p_ni:  7.4e-8
Score:  0.666
Data Source:  BioPlex,STRINGDB
TCF12
Tbio
Family:  TF
Novelty:  0.00381424
p_int:  0.999999611
p_ni:  3.89e-7
Score:  0.584
Data Source:  BioPlex,STRINGDB
TEP1
Tbio
Family:  Enzyme
Novelty:  0.01254647
p_int:  0.99999858
p_ni:  0.00000136
p_wrong:  6e-8
Score:  0.203
Data Source:  BioPlex,STRINGDB
DCAF4
Tbio
Novelty:  0.24190895
p_int:  0.999992496
p_ni:  0.000007504
Data Source:  BioPlex
ARID3B
Tbio
Family:  TF
Novelty:  0.0691591
p_int:  0.999991526
p_ni:  0.000008474
Score:  0.17
Data Source:  BioPlex,STRINGDB
RMDN2
Tbio
Novelty:  0.10425524
p_int:  0.999990226
p_ni:  0.000009167
p_wrong:  6.08e-7
Score:  0.263
Data Source:  BioPlex,STRINGDB
HES6
Tbio
Family:  TF
Novelty:  0.01546524
p_int:  0.999970018
p_ni:  2e-9
p_wrong:  0.00002998
Score:  0.41
Data Source:  BioPlex,STRINGDB
ZNF100
Tdark
Family:  TF
Novelty:  0.74439926
p_int:  0.999945787
p_ni:  0.000054175
p_wrong:  3.9e-8
Score:  0.197
Data Source:  BioPlex,STRINGDB
YY1AP1
Tbio
Novelty:  0.06862573
p_int:  0.999906062
p_ni:  0.000093935
p_wrong:  4e-9
Score:  0.519
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of beta-cell development
Reactome
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Reactome
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of beta-cell development
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1
1
1.3
84.9
reticulocyte measurement
3
2
3
81.3
reticulocyte count
2
2
2
81
HbA1c measurement
1
2
2
74
6
2
3
1.1
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.3
84.9
reticulocyte measurement
3
81.3
reticulocyte count
2
81
HbA1c measurement
2
74
3
1.1
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurogenin 3
VGNC:12387
748874
Macaque
neurogenin 3
711583
Mouse
MGI:893591
11925
Rat
RGD:631350
60329
Dog
neurogenin 3
VGNC:43758
489022
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurogenin 3
Macaque
neurogenin 3
Mouse
Rat
Dog
neurogenin 3
Publication Statistics
PubMed Score 337.41
PubMed score by year
PubTator Score 150.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title