Protein Summary
Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
- ENST00000242462
- ENSP00000242462
- ENSG00000122859
- ATOH5
- BHLHA7
- NGN3
- ngn3
- Atoh5
- NGN-3
- Math4B
- bHLHa7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.98 | ||
biological process | 0.84 | ||
PubMedID | 0.63 | ||
cell type or tissue | 0.59 | ||
tissue | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 337.41 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 522 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 337.41 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 522 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (159)
TCF3
Family: TF
Novelty: 0.00112675
p_int: 0.999999935
p_ni: 6.5e-8
Score: 0.561
Data Source: BioPlex,STRINGDB
TCF4
Family: TF
Novelty: 0.0019718
p_int: 0.999999926
p_ni: 7.4e-8
Score: 0.666
Data Source: BioPlex,STRINGDB
TCF12
Family: TF
Novelty: 0.00381424
p_int: 0.999999611
p_ni: 3.89e-7
Score: 0.584
Data Source: BioPlex,STRINGDB
TEP1
Family: Enzyme
Novelty: 0.01254647
p_int: 0.99999858
p_ni: 0.00000136
p_wrong: 6e-8
Score: 0.203
Data Source: BioPlex,STRINGDB
ARID3B
Family: TF
Novelty: 0.0691591
p_int: 0.999991526
p_ni: 0.000008474
Score: 0.17
Data Source: BioPlex,STRINGDB
RMDN2
Novelty: 0.10425524
p_int: 0.999990226
p_ni: 0.000009167
p_wrong: 6.08e-7
Score: 0.263
Data Source: BioPlex,STRINGDB
HES6
Family: TF
Novelty: 0.01546524
p_int: 0.999970018
p_ni: 2e-9
p_wrong: 0.00002998
Score: 0.41
Data Source: BioPlex,STRINGDB
ZNF100
Family: TF
Novelty: 0.74439926
p_int: 0.999945787
p_ni: 0.000054175
p_wrong: 3.9e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
YY1AP1
Novelty: 0.06862573
p_int: 0.999906062
p_ni: 0.000093935
p_wrong: 4e-9
Score: 0.519
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (4)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Regulation of beta-cell development | ||||
Reactome | Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells | ||||
Reactome | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Developmental Biology | ||||
Regulation of beta-cell development | ||||
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells | ||||
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (7)
Components (2)
Processes (14)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
4 | 1 | 1 | 1.3 | 84.9 | |||||
reticulocyte measurement | 3 | 2 | 3 | 81.3 | |||||
reticulocyte count | 2 | 2 | 2 | 81 | |||||
HbA1c measurement | 1 | 2 | 2 | 74 | |||||
6 | 2 | 3 | 1.1 | 70.2 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
1 | 1.3 | 84.9 | |||||
reticulocyte measurement | 3 | 81.3 | |||||
reticulocyte count | 2 | 81 | |||||
HbA1c measurement | 2 | 74 | |||||
3 | 1.1 | 70.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | neurogenin 3 | VGNC:12387 | 748874 | |||||
Macaque | neurogenin 3 | 711583 | ||||||
Mouse | MGI:893591 | 11925 | ||||||
Rat | RGD:631350 | 60329 | ||||||
Dog | neurogenin 3 | VGNC:43758 | 489022 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | neurogenin 3 | |||||
Macaque | neurogenin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | neurogenin 3 | |||||
Publication Statistics
PubMed Score 337.41
PubMed score by year
PubTator Score 150.46
PubTator score by year
Related Publications
Text Mined References (49)
GeneRif Annotations (34)
Items per page:
0 of 0
PMID | Year | Title |
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