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Tbio
NEUROD2
Neurogenic differentiation factor 2

Protein Summary
Description
Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity). This gene encodes a member of the neuroD family of neuro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302584
  • ENSP00000306754
  • ENSG00000171532

Symbol
  • BHLHA1
  • NDRF
  • NDRF
  • bHLHa1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
molecular function
0.84
disease perturbation
0.68
transcription factor
0.63
PubMedID
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.72   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.72   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
CPLX2
Tbio
Novelty:  0.01821493
Score:  0.826
Data Source:  STRINGDB
CDC20
Tbio
Novelty:  0.00197887
Score:  0.82
Data Source:  STRINGDB
MYT1L
Tbio
Family:  TF
Novelty:  0.0174369
Score:  0.758
Data Source:  STRINGDB
ANAPC1
Tbio
Family:  Enzyme
Novelty:  0.0521845
Score:  0.718
Data Source:  STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
Score:  0.696
Data Source:  STRINGDB
ASCL1
Tbio
Family:  TF
Novelty:  0.00274239
Score:  0.682
Data Source:  STRINGDB
TBR1
Tbio
Family:  TF
Novelty:  0.00676736
Score:  0.648
Data Source:  STRINGDB
CKS1B
Tbio
Family:  Enzyme
Novelty:  0.00766779
Score:  0.575
Data Source:  STRINGDB
POU3F2
Tbio
Family:  TF
Novelty:  0.00649458
Score:  0.556
Data Source:  STRINGDB
PGAP3
Tbio
Novelty:  0.01842385
Score:  0.535
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
10
9
18
98.1
glomerular filtration rate
3
3
3
95
alkaline phosphatase measurement
2
2
1
11.6
93.4
2
2
0
1.1
89.1
hemoglobin measurement
2
2
2
84.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
18
98.1
glomerular filtration rate
3
95
alkaline phosphatase measurement
1
11.6
93.4
0
1.1
89.1
hemoglobin measurement
2
84.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neuronal differentiation 2
696976
Mouse
MGI:107755
18013
Dog
neuronal differentiation 2
VGNC:43753
491026
Horse
neuronal differentiation 2
VGNC:20693
100054920
Cow
neuronal differentiation 2
VGNC:32018
528817
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neuronal differentiation 2
Mouse
Dog
neuronal differentiation 2
Horse
neuronal differentiation 2
Cow
neuronal differentiation 2
Publication Statistics
PubMed Score 60.72
PubMed score by year
PubTator Score 17.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title