Tbio NEUROD1 Neurogenic differentiation factor 1

Protein Summary

Description

Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13562
• B2R9I8
• F1T0E1
• O00343
• Q13340
• Q5U095
• Q96TH0
• Q99455
• Q9UEC8
• NeuroD

Gene Name

• NEUROD1

Ensembl ID

• ENST00000295108
• ENSP00000295108
• ENSG00000162992

Symbol

• BHLHA3
• NEUROD
• BETA2
• BHF-1
• MODY6
• NEUROD
• bHLHa3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
molecular function	0.99
hub protein	0.75
PubMedID	0.71
gene perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Neurogenic Differentiation Factor 1

Protein / Nucleic Acid Binding / Nuclease / Neurogenic Differentiation Factor 1

DTO Classes

Protein / Enzyme / Nuclease / Neurogenic Differentiation Factor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.61   (req: < 5)

Gene RIFs: 79   (req: <= 3)

Antibodies: 470   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.61   (req: >= 5)

Gene RIFs: 79   (req: > 3)

Antibodies: 470   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0