You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
NEURL4
Neuralized-like protein 4

Protein Summary
Description
Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315614
  • ENSP00000319826
  • ENSG00000215041
  • ENST00000399464
  • ENSP00000382390

Symbol
  • KIAA1787
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
virus perturbation
0.76
disease perturbation
0.74
transcription factor
0.53
transcription factor binding site profile
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.18   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.18   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
FBXL5
Tbio
Novelty:  0.03103624
p_int:  0.999990898
p_ni:  0.000009102
Score:  0.504
Data Source:  BioPlex,STRINGDB
DBNL
Tbio
Novelty:  0.03390948
p_int:  0.9999878
p_ni:  0.0000122
Score:  0.198
Data Source:  BioPlex,STRINGDB
MAP7D2
Tdark
Novelty:  0.70744439
p_int:  0.99996757
p_ni:  0.00003243
Data Source:  BioPlex
APBB1
Tbio
Novelty:  0.00630564
p_int:  0.999958715
p_ni:  0.000041285
Score:  0.183
Data Source:  BioPlex,STRINGDB
PPL
Tbio
Novelty:  0.00684645
p_int:  0.999939543
p_ni:  0.000060444
p_wrong:  1.4e-8
Data Source:  BioPlex
CCDC136
Tbio
Novelty:  0.09279967
p_int:  0.999868712
p_ni:  0.000131288
Score:  0.166
Data Source:  BioPlex,STRINGDB
ZNF286A
Tdark
Family:  TF
Novelty:  3
p_int:  0.999578294
p_ni:  0.000421705
p_wrong:  1e-9
Data Source:  BioPlex
MAPK6
Tbio
Family:  Kinase
Novelty:  0.01012514
p_int:  0.999502594
p_ni:  0.000497402
p_wrong:  4e-9
Score:  0.651
Data Source:  BioPlex,STRINGDB
PRIMPOL
Tbio
Family:  Enzyme
Novelty:  0.01285041
p_int:  0.999471442
p_ni:  0.000528557
Score:  0.159
Data Source:  BioPlex,STRINGDB
SPZ1
Tbio
Family:  TF
Novelty:  0.07156505
p_int:  0.999361613
p_ni:  0.000638387
Score:  0.211
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
4
4
97
alkaline phosphatase measurement
1
3
3
95.8
birth weight
4
3
4
89.4
apolipoprotein B measurement
2
3
3
87.8
myeloid white cell count
1
1
1
79.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
97
alkaline phosphatase measurement
3
95.8
birth weight
4
89.4
apolipoprotein B measurement
3
87.8
myeloid white cell count
1
79.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1921092
216860
Rat
RGD:1308056
303248
Cow
neuralized E3 ubiquitin protein ligase 4
VGNC:54462
528485
Pig
neuralized E3 ubiquitin protein ligase 4
100625193
Opossum
neuralized E3 ubiquitin protein ligase 4
100616800
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
neuralized E3 ubiquitin protein ligase 4
Pig
neuralized E3 ubiquitin protein ligase 4
Opossum
neuralized E3 ubiquitin protein ligase 4
Publication Statistics
PubMed Score 4.18
PubMed score by year
PubTator Score 2.43
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title