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Tbio
NEURL2
Neuralized-like protein 2

Protein Summary
Description
Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity). This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372518
  • ENSP00000361596
  • ENSG00000124257

Symbol
  • C20orf163
  • OZZ
  • OZZ-E3
  • C20orf163
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor binding site profile
0.76
transcription factor
0.62
tissue sample
0.61
virus perturbation
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.21   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.21   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (171)
CISH
Tbio
Novelty:  0.00145893
Score:  0.952
Data Source:  STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.939
Data Source:  STRINGDB
ELOB
Tbio
Novelty:  0.01315739
Score:  0.937
Data Source:  STRINGDB
CUL5
Tbio
Novelty:  0.00792494
Score:  0.936
Data Source:  STRINGDB
ASB1
Tdark
Novelty:  0.0931554
Score:  0.933
Data Source:  STRINGDB
ASB18
Tdark
Novelty:  1.29585637
Score:  0.933
Data Source:  STRINGDB
FBXO32
Tbio
Novelty:  0.00225437
Score:  0.931
Data Source:  STRINGDB
ASB17
Tbio
Novelty:  0.0979661
Score:  0.923
Data Source:  STRINGDB
ASB11
Tdark
Novelty:  0.84862254
Score:  0.921
Data Source:  STRINGDB
ASB4
Tbio
Novelty:  0.09903118
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (56)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
94
25
115
99.8
triglyceride measurement
38
17
48
3.3
99.7
lipid measurement
18
7
19
99
lipoprotein measurement
2
3
3
96.6
free cholesterol measurement
15
8
16
96.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
115
99.8
triglyceride measurement
48
3.3
99.7
lipid measurement
19
99
lipoprotein measurement
3
96.6
free cholesterol measurement
16
96.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuralized E3 ubiquitin protein ligase 2
VGNC:6211
469958
Mouse
MGI:3043305
415115
Rat
RGD:1306409
311633
Dog
neuralized E3 ubiquitin protein ligase 2
VGNC:43751
477248
Horse
neuralized E3 ubiquitin protein ligase 2
VGNC:20691
100071119
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuralized E3 ubiquitin protein ligase 2
Mouse
Rat
Dog
neuralized E3 ubiquitin protein ligase 2
Horse
neuralized E3 ubiquitin protein ligase 2
Publication Statistics
PubMed Score 6.21
PubMed score by year
PubTator Score 1.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title