You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NEU4
Sialidase-4

Protein Summary
Description
May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids. The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325935
  • ENSP00000320318
  • ENSG00000204099
  • ENST00000391969
  • ENSP00000375830
  • ENST00000404257
  • ENSP00000385149
  • ENST00000405370
  • ENSP00000384804
  • ENST00000407683
  • ENSP00000385402
  • ENST00000616490
  • ENSP00000482722
  • ENSG00000277926
  • ENST00000618866
  • ENSP00000483726
  • ENST00000621851
  • ENSP00000478409
  • ENST00000626600
  • ENSP00000485701
  • ENST00000630923
  • ENSP00000486602
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.74
pathway
0.73
cell type or tissue
0.72
virus perturbation
0.72
tissue sample
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.64   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.64   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0