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Tbio
NES
Nestin

Protein Summary
Description
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368223
  • ENSP00000357206
  • ENSG00000132688

Symbol
  • Nbla00170
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
PubMedID
0.9
transcription factor binding site profile
0.81
disease
0.8
drug perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3124.65   (req: < 5)
Gene RIFs: 193   (req: <= 3)
Antibodies: 988   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3124.65   (req: >= 5)
Gene RIFs: 193   (req: > 3)
Antibodies: 988   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (292)
VIM
Tbio
Novelty:  0.00030317
p_int:  0.999998286
p_ni:  0.00000171
p_wrong:  4e-9
Score:  0.864
Data Source:  BioPlex,STRINGDB
NEFM
Tbio
Novelty:  0.00239134
p_int:  0.999996297
p_ni:  0.000003703
Score:  0.864
Data Source:  BioPlex,STRINGDB
MYF6
Tbio
Family:  TF
Novelty:  0.00509046
p_int:  0.999989783
p_ni:  0.000010217
Score:  0.706
Data Source:  BioPlex,STRINGDB
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.999979728
p_ni:  0.000020268
p_wrong:  5e-9
Score:  0.534
Data Source:  BioPlex,STRINGDB
GFAP
Tbio
Novelty:  0.00020932
p_int:  0.999583129
p_ni:  0.000416871
Score:  0.805
Data Source:  BioPlex,STRINGDB
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.998995089
p_ni:  0.001004908
p_wrong:  3e-9
Data Source:  BioPlex
FERD3L
Tbio
Family:  TF
Novelty:  0.06797434
p_int:  0.99466977
p_ni:  0.0053302
p_wrong:  3e-8
Score:  0.574
Data Source:  BioPlex,STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
p_int:  0.993240337
p_ni:  0.006759217
p_wrong:  4.46e-7
Score:  0.881
Data Source:  BioPlex,STRINGDB
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.991298502
p_ni:  0.008688095
p_wrong:  0.000013403
Score:  0.706
Data Source:  BioPlex,STRINGDB
CAPN1
Tchem
Novelty:  0.00252811
p_int:  0.982028998
p_ni:  0.017970681
p_wrong:  3.21e-7
Score:  0.647
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
3
3
84.7
neuroimaging measurement
10
1
10
46.3
leukocyte count
2
1
2
33.4
neutrophil count
1
1
1
28.9
bilirubin measurement
2
2
2
22.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
84.7
neuroimaging measurement
10
46.3
leukocyte count
2
33.4
neutrophil count
1
28.9
bilirubin measurement
2
22.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nestin
VGNC:1346
742303
Macaque
nestin
718562
Mouse
MGI:101784
18008
Rat
RGD:3162
25491
Dog
nestin
VGNC:53625
490410
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nestin
Macaque
nestin
Mouse
Rat
Dog
nestin
Publication Statistics
PubMed Score 3124.65
PubMed score by year
PubTator Score 436.93
PubTator score by year
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Related Publications
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PMID
Year
Title