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Tbio
NEPRO
Nucleolus and neural progenitor protein

Protein Summary
Description
May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314400
  • ENSP00000320251
  • ENSG00000163608
  • ENST00000383675
  • ENSP00000373173

Symbol
  • C3orf17
  • NET17
  • C3orf17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.96   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.96   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
POP5
Tbio
Family:  Enzyme
Novelty:  0.02459167
p_int:  0.999998272
p_ni:  0.000001728
Data Source:  BioPlex
RPP30
Tbio
Family:  Enzyme
Novelty:  0.01375777
p_int:  0.999993817
p_ni:  0.000006183
Score:  0.823
Data Source:  BioPlex,STRINGDB
C18orf21
Tdark
Novelty:  0.65363998
p_int:  0.999937888
p_ni:  0.000062112
p_wrong:  1e-9
Score:  0.828
Data Source:  BioPlex,STRINGDB
RPP14
Tbio
Family:  Enzyme
Novelty:  0.10813341
p_int:  0.999737001
p_ni:  0.000103964
p_wrong:  0.000159036
Score:  0.344
Data Source:  BioPlex,STRINGDB
POP4
Tbio
Family:  Enzyme
Novelty:  0.01072287
p_int:  0.999355093
p_ni:  0.000644849
p_wrong:  5.8e-8
Score:  0.842
Data Source:  BioPlex,STRINGDB
RPP25
Tbio
Family:  Enzyme
Novelty:  0.07178063
p_int:  0.999299342
p_ni:  0.000700657
p_wrong:  1e-9
Score:  0.88
Data Source:  BioPlex,STRINGDB
RPP40
Tbio
Family:  Enzyme
Novelty:  0.05981624
p_int:  0.998912226
p_ni:  0.001087771
p_wrong:  3e-9
Score:  0.357
Data Source:  BioPlex,STRINGDB
RPP38
Tbio
Family:  Enzyme
Novelty:  0.06387902
p_int:  0.99746468
p_ni:  0.00253532
Score:  0.183
Data Source:  BioPlex,STRINGDB
RPP25L
Tdark
Family:  Enzyme
Novelty:  1.39761189
p_int:  0.996994228
p_ni:  0.003005028
p_wrong:  7.45e-7
Score:  0.421
Data Source:  BioPlex,STRINGDB
POP1
Tbio
Family:  Enzyme
Novelty:  2.92497626
p_int:  0.994294283
p_ni:  0.005705717
Score:  0.161
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
86.6
eosinophil percentage of leukocytes
1
1
1
75.1
sum of eosinophil and basophil counts
1
1
1
40.7
1
1
0
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
86.6
eosinophil percentage of leukocytes
1
75.1
sum of eosinophil and basophil counts
1
40.7
0
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleolus and neural progenitor protein
VGNC:5027
460587
Macaque
nucleolus and neural progenitor protein
708933
Mouse
MGI:2384836
212547
Rat
RGD:1311458
303948
Dog
nucleolus and neural progenitor protein
VGNC:43746
607614
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleolus and neural progenitor protein
Macaque
nucleolus and neural progenitor protein
Mouse
Rat
Dog
nucleolus and neural progenitor protein
Publication Statistics
PubMed Score 5.96
PubMed score by year
PubTator Score 1.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title