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Tbio
NEO1
Neogenin

Protein Summary
Description
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in mul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261908
  • ENSP00000261908
  • ENSG00000067141
  • ENST00000339362
  • ENSP00000341198
  • ENST00000558964
  • ENSP00000453200
  • ENST00000560262
  • ENSP00000453317

Symbol
  • IGDCC2
  • NGN
  • NGN
  • IGDCC2
  • NTN1R2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.98
protein domain
0.92
histone modification site profile
0.85
gene perturbation
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.34   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.34   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.999702247
p_ni:  0.000008868
p_wrong:  0.000288885
Data Source:  BioPlex
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.877760072
p_ni:  0.000061963
p_wrong:  0.122177966
Data Source:  BioPlex
MFAP5
Tbio
Novelty:  0.01839035
p_int:  0.833651725
p_ni:  0.000005481
p_wrong:  0.166342794
Data Source:  BioPlex
TNF
Tclin
Novelty:  0.00001457
p_int:  0.810306437
p_ni:  0.000023872
p_wrong:  0.18966969
Score:  0.368
Data Source:  BioPlex,STRINGDB
NTN1
Tbio
Novelty:  0.00183678
Score:  0.995
Data Source:  Reactome,STRINGDB
RGMA
Tbio
Novelty:  0.00549021
Score:  0.995
Data Source:  Reactome,STRINGDB
HJV
Tbio
Novelty:  0.00495995
Score:  0.993
Data Source:  Reactome,STRINGDB
RGMB
Tbio
Novelty:  0.05317349
Score:  0.984
Data Source:  Reactome,STRINGDB
NTN3
Tbio
Novelty:  0.10657622
Score:  0.98
Data Source:  Reactome,STRINGDB
CDON
Tbio
Novelty:  0.00447262
Score:  0.947
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Myogenesis
Reactome
Netrin-1 signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Myogenesis
Netrin-1 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.1
94
mean corpuscular hemoglobin concentration
1
1
1
71.6
heart rate variability measurement
2
2
6
60.8
red blood cell distribution width
1
1
1
52.7
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
94
mean corpuscular hemoglobin concentration
1
71.6
heart rate variability measurement
6
60.8
red blood cell distribution width
1
52.7
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neogenin 1
VGNC:1909
453730
Macaque
neogenin 1
705160
Mouse
MGI:1097159
18007
Rat
RGD:619837
81735
Dog
neogenin 1
VGNC:43745
487635
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neogenin 1
Macaque
neogenin 1
Mouse
Rat
Dog
neogenin 1
Publication Statistics
PubMed Score 167.34
PubMed score by year
PubTator Score 93.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title