Protein Summary
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in mul ...more
- ENST00000261908
- ENSP00000261908
- ENSG00000067141
- ENST00000339362
- ENSP00000341198
- ENST00000558964
- ENSP00000453200
- ENST00000560262
- ENSP00000453317
- IGDCC2
- NGN
- NGN
- IGDCC2
- NTN1R2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.98 | ||
protein domain | 0.92 | ||
histone modification site profile | 0.85 | ||
gene perturbation | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.34 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 178 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.34 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 178 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (106)
CTLA4
Novelty: 0.00012781
p_int: 0.999702247
p_ni: 0.000008868
p_wrong: 0.000288885
Data Source: BioPlex
CLEC4A
Novelty: 0.01821643
p_int: 0.877760072
p_ni: 0.000061963
p_wrong: 0.122177966
Data Source: BioPlex
MFAP5
Novelty: 0.01839035
p_int: 0.833651725
p_ni: 0.000005481
p_wrong: 0.166342794
Data Source: BioPlex
TNF
Novelty: 0.00001457
p_int: 0.810306437
p_ni: 0.000023872
p_wrong: 0.18966969
Score: 0.368
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (4)
KEGG (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | Myogenesis | ||||
Reactome | Netrin-1 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
Myogenesis | ||||
Netrin-1 signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (5)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
4 | 4 | 0 | 1.1 | 94 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 71.6 | |||||
heart rate variability measurement | 2 | 2 | 6 | 60.8 | |||||
red blood cell distribution width | 1 | 1 | 1 | 52.7 | |||||
1 | 1 | 1 | 40.7 | ||||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 94 | |||||
mean corpuscular hemoglobin concentration | 1 | 71.6 | |||||
heart rate variability measurement | 6 | 60.8 | |||||
red blood cell distribution width | 1 | 52.7 | |||||
1 | 40.7 | ||||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | neogenin 1 | VGNC:1909 | 453730 | |||||
Macaque | neogenin 1 | 705160 | ||||||
Mouse | MGI:1097159 | 18007 | ||||||
Rat | RGD:619837 | 81735 | ||||||
Dog | neogenin 1 | VGNC:43745 | 487635 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | neogenin 1 | |||||
Macaque | neogenin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | neogenin 1 | |||||
Publication Statistics
PubMed Score 167.34
PubMed score by year
PubTator Score 93.10
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (32)
Items per page:
0 of 0
PMID | Year | Title |
|---|