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Tbio
NELL1
Protein kinase C-binding protein NELL1

Protein Summary
Description
Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357134
  • ENSP00000349654
  • ENSG00000165973
  • ENST00000532434
  • ENSP00000437170

Symbol
  • NRP1
  • NRP1
  • IDH3GL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
phenotype
0.77
disease
0.67
PubMedID
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.22   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.22   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
MATN2
Tbio
Novelty:  0.08506252
p_int:  0.999846725
p_ni:  7.73e-7
p_wrong:  0.000152502
Score:  0.213
Data Source:  BioPlex,STRINGDB
PFKP
Tbio
Family:  Kinase
Novelty:  0.00808684
p_int:  0.999753531
p_ni:  0.000246469
Score:  0.187
Data Source:  BioPlex,STRINGDB
FBXO27
Tdark
Novelty:  0.27910336
p_int:  0.999404635
p_ni:  0.000008366
p_wrong:  0.000586999
Score:  0.209
Data Source:  BioPlex,STRINGDB
PXDN
Tbio
Novelty:  0.00935722
p_int:  0.999371785
p_ni:  0.000628215
Data Source:  BioPlex
ZNF260
Tdark
Family:  TF
Novelty:  0.38314831
p_int:  0.999149011
p_ni:  0.000002158
p_wrong:  0.000848831
Score:  0.289
Data Source:  BioPlex,STRINGDB
TRMT2B
Tdark
Family:  Enzyme
Novelty:  0.12373575
p_int:  0.998928492
p_ni:  0.001071508
p_wrong:  1e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
EMILIN2
Tbio
Novelty:  0.2816786
p_int:  0.998704077
p_ni:  0.001295891
p_wrong:  3.2e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
TP53RK
Tbio
Family:  Kinase
Novelty:  0.04302252
p_int:  0.997804077
p_ni:  0.002195923
Score:  0.183
Data Source:  BioPlex,STRINGDB
TIMP3
Tbio
Family:  Enzyme
Novelty:  0.00134742
p_int:  0.996814764
p_ni:  0.003185232
p_wrong:  4e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
EGFL7
Tbio
Novelty:  0.01148912
p_int:  0.993532882
p_ni:  0.006467118
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cardiac troponin I measurement
3
2
2
6.1
93.9
blood protein measurement
2
2
3
86.8
creatine kinase measurement
1
1
1
73.2
aspartate aminotransferase measurement
1
1
0
10.5
67.8
serum alanine aminotransferase measurement
2
1
1
6.2
63.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cardiac troponin I measurement
2
6.1
93.9
blood protein measurement
3
86.8
creatine kinase measurement
1
73.2
aspartate aminotransferase measurement
0
10.5
67.8
serum alanine aminotransferase measurement
1
6.2
63.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neural EGFL like 1
701438
Mouse
MGI:2443902
338352
Rat
RGD:620998
81733
Dog
neural EGFL like 1
VGNC:43739
476888
Horse
neural EGFL like 1
VGNC:20680
100057422
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neural EGFL like 1
Mouse
Rat
Dog
neural EGFL like 1
Horse
neural EGFL like 1
Publication Statistics
PubMed Score 123.22
PubMed score by year
PubTator Score 58.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title