Tbio NELFB Negative elongation factor B

Protein Summary

Description

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. May be able to induce chromatin unfolding. NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8WX92
• A2BFA3
• Q96EW5
• Q9H9R4
• Q9ULN8
• Q9Y3W0
• NELF-B

Gene Name

• NELFB

Ensembl ID

• ENST00000634710
• ENSP00000489248
• ENSG00000188986

Symbol

• COBRA1
• KIAA1182
• COBRA1
• NELF-B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
histone modification site profile	0.91
co-expressed gene	0.89
pathway	0.78
hub protein	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.91   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 203   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.91   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (113)

Explore Interacting Targets

1 – 10 of 113

• See Interactions on String-DB

NELFE

Tbio

Novelty:  0.02136256

p_int:  0.999999983

p_ni:  1e-8

p_wrong:  7e-9

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

NELFA

Tbio

Novelty:  0.09727823

p_int:  0.99999998

p_ni:  1.7e-8

p_wrong:  3e-9

Score:  0.996

Data Source:  BioPlex,Reactome,STRINGDB

FECH

Tchem

Family:  Enzyme

Novelty:  0.00282289

p_int:  0.999994081

p_ni:  0.000005919

Score:  0.768

Data Source:  BioPlex,STRINGDB

CYP2J2

Tchem

Novelty:  0.00534181

p_int:  0.999879617

p_ni:  0.000120383

Data Source:  BioPlex

ANK1

Tbio

Novelty:  0.00225305

p_int:  0.932192192

p_ni:  0.067047519

p_wrong:  0.000760289

Score:  0.224

Data Source:  BioPlex,STRINGDB

NELFCD

Tbio

Novelty:  0.00094754

Score:  0.994

Data Source:  Reactome,STRINGDB

SUPT5H

Tbio

Novelty:  0.00775042

Score:  0.992

Data Source:  Reactome,STRINGDB

NCBP1

Tbio

Novelty:  0.01228885

Score:  0.99

Data Source:  Reactome,STRINGDB

SUPT4H1

Tbio

Novelty:  0.0127914

Score:  0.988

Data Source:  Reactome,STRINGDB

CDC5L

Tbio

Family:  TF

Novelty:  0.00663599

Score:  0.982

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (32)

Reactome (30)

WikiPathways (2)

Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 30

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Abortive elongation of HIV-1 transcript in the absence of Tat	23 targets	R-HSA-167242
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Formation of HIV elongation complex in the absence of HIV Tat	48 targets	R-HSA-167152
Reactome	Formation of HIV-1 elongation complex containing HIV-1 Tat	47 targets	R-HSA-167200
Reactome	Formation of RNA Pol II elongation complex	61 targets	R-HSA-112382

Name	Explore in Pharos	Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat	23 targets	R-HSA-167242
Disease	1105 targets	R-HSA-1643685
Formation of HIV elongation complex in the absence of HIV Tat	48 targets	R-HSA-167152
Formation of HIV-1 elongation complex containing HIV-1 Tat	47 targets	R-HSA-167200
Formation of RNA Pol II elongation complex	61 targets	R-HSA-112382

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (3)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
RNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (16)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	4	2	3	1.1	90.8
glomerular filtration rate	EFO_0005208	3	3	4		89.1
creatinine measurement	EFO_0004518	1	2	2		86.1
mathematical ability	EFO_0004875	4	2	4		85.2
reticulocyte measurement	EFO_0010700	3	1	3		82.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	3	1.1	90.8
glomerular filtration rate	EFO_0005208	4		89.1
creatinine measurement	EFO_0004518	2		86.1
mathematical ability	EFO_0004875	4		85.2
reticulocyte measurement	EFO_0010700	3		82.3

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Nucleus
Phosphoprotein
Reference proteome
Repressor
RNA-binding
Transcription

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
chronotype measurement
circadian rhythm
cognitive function measurement
creatinine measurement
eosinophil percentage of leukocytes
glomerular filtration rate
HbA1c measurement
insomnia measurement
mathematical ability

MGI Phenotype Find Similar Targets

No Header	No Header
embryo phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	negative elongation factor complex member B	VGNC:13923	736409
Macaque	negative elongation factor complex member B		704966
Mouse	negative elongation factor complex member B	MGI:1931035	58202
Rat	negative elongation factor complex member B	RGD:1307832	311796
Dog	negative elongation factor complex member B	VGNC:43737	491230

Species	Name	OMA	EggNOG	Inparanoid
Chimp	negative elongation factor complex member B
Macaque	negative elongation factor complex member B
Mouse	negative elongation factor complex member B
Rat	negative elongation factor complex member B
Dog	negative elongation factor complex member B

Publication Statistics

PubMed Score 24.91

PubMed score by year

Reset Zoom

PubTator Score 10.85

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (38)

GeneRif Annotations (17)

Items per page:

10

0 of 0

PMID	Year	Title