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Tchem
NEK1
Serine/threonine-protein kinase Nek1

Protein Summary
Description
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000439128
  • ENSP00000408020
  • ENSG00000137601
  • ENST00000507142
  • ENSP00000424757
  • ENST00000510533
  • ENSP00000427653
  • ENST00000511633
  • ENSP00000423332
  • ENST00000512193
  • ENSP00000424938

Symbol
  • KIAA1901
  • ALS24
  • SRPS2
  • SRTD6
  • SRPS2A
  • NY-REN-55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
molecular function
0.96
transcription factor perturbation
0.91
virus perturbation
0.88
transcription factor binding site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.54   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.54   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 165
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (165)
staurosporine
Rendered image for staurosporine
compound 31 [PMID: 20936789]
Rendered image for compound 31 [PMID: 20936789]
CHEMBL3672295,CHEMBL4537262
Rendered image for CHEMBL3672295,CHEMBL4537262
US8962648, 1122
Rendered image for US8962648, 1122
CHEMBL3667204
Rendered image for CHEMBL3667204
US8962648, 319
Rendered image for US8962648, 319
US8962648, 276
Rendered image for US8962648, 276
US8962648, 275
Rendered image for US8962648, 275
US8962648, 235
Rendered image for US8962648, 235
US8962648, 1160
Rendered image for US8962648, 1160
Protein-Protein Interactions (88)
TTC25
Tdark
Novelty:  0.23064129
p_int:  0.999999751
p_ni:  2.49e-7
Score:  0.208
Data Source:  BioPlex,STRINGDB
TEKT4
Tbio
Novelty:  0.05559086
p_int:  0.999999299
p_ni:  7.01e-7
Score:  0.218
Data Source:  BioPlex,STRINGDB
ALS2
Tbio
Novelty:  0.0072324
p_int:  0.999998737
p_ni:  0.000001263
Score:  0.473
Data Source:  BioPlex,STRINGDB
VPS26B
Tdark
Novelty:  0.25702869
p_int:  0.99999243
p_ni:  0.00000757
Score:  0.2
Data Source:  BioPlex,STRINGDB
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.999991422
p_ni:  0.000008578
Data Source:  BioPlex
CPNE2
Tdark
Novelty:  0.24188419
p_int:  0.999989789
p_ni:  0.000010211
Data Source:  BioPlex
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.999810206
p_ni:  0.000189793
Data Source:  BioPlex
KIF2B
Tbio
Novelty:  0.09958244
p_int:  0.968363949
p_ni:  0.031634069
p_wrong:  0.000001981
Score:  0.157
Data Source:  BioPlex,STRINGDB
CTDSP2
Tbio
Family:  Enzyme
Novelty:  0.01033594
p_int:  0.922174892
p_ni:  0.074947219
p_wrong:  0.002877889
Score:  0.159
Data Source:  BioPlex,STRINGDB
VTN
Tbio
Family:  TF
Novelty:  0.00046861
p_int:  0.864528689
p_ni:  0.116245427
p_wrong:  0.019225884
Score:  0.181
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Mutant Phenotype (IMP)
CACAO
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
2
0
1.1
48.3
1
1
0
1.1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
48.3
0
1.1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NIMA related kinase 1
VGNC:6478
471345
Macaque
NIMA related kinase 1
694345
Mouse
MGI:97303
18004
Rat
RGD:1309375
290705
Dog
NIMA related kinase 1
VGNC:43729
486058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NIMA related kinase 1
Macaque
NIMA related kinase 1
Mouse
Rat
Dog
NIMA related kinase 1
Publication Statistics
PubMed Score 65.54
PubMed score by year
PubTator Score 29.33
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title