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Tbio
NEGR1
Neuronal growth regulator 1

Protein Summary
Description
May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306821
  • ENSP00000305938
  • ENSG00000172260
  • ENST00000357731
  • ENSP00000350364

Symbol
  • IGLON4
  • Ntra
  • KILON
  • IGLON4
  • DMML2433
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
microRNA
0.86
protein domain
0.73
transcription factor binding site profile
0.7
disease
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.83   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.83   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (168)
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.974753006
p_ni:  0.025246974
p_wrong:  2e-8
Data Source:  BioPlex
GET4
Tbio
Novelty:  0.03516005
p_int:  0.800895729
p_ni:  0.199104271
Data Source:  BioPlex
NTM
Tbio
Novelty:  0.01659865
Score:  0.954
Data Source:  STRINGDB
LSAMP
Tbio
Novelty:  0.01237032
Score:  0.949
Data Source:  STRINGDB
OPCML
Tbio
Novelty:  0.01569352
Score:  0.945
Data Source:  STRINGDB
NRN1
Tbio
Novelty:  0.01198116
Score:  0.93
Data Source:  STRINGDB
NTNG1
Tbio
Novelty:  0.04742965
Score:  0.923
Data Source:  STRINGDB
NTNG2
Tbio
Novelty:  0.02827688
Score:  0.92
Data Source:  STRINGDB
PRND
Tbio
Novelty:  0.00645201
Score:  0.919
Data Source:  STRINGDB
CNTN4
Tbio
Novelty:  0.02483465
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
19
10
27
2.5
98
10
8
5
1
97.6
self reported educational attainment
6
10
9
4.2
97.4
cognitive function measurement
3
4
8
93.3
mathematical ability
4
8
12
92.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
27
2.5
98
5
1
97.6
self reported educational attainment
9
4.2
97.4
cognitive function measurement
8
93.3
mathematical ability
12
92.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuronal growth regulator 1
VGNC:53225
456941
Macaque
neuronal growth regulator 1
703636
Mouse
MGI:2444846
320840
Rat
RGD:708416
59318
Dog
neuronal growth regulator 1
VGNC:54049
612706
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuronal growth regulator 1
Macaque
neuronal growth regulator 1
Mouse
Rat
Dog
neuronal growth regulator 1
Publication Statistics
PubMed Score 121.83
PubMed score by year
PubTator Score 37.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title