You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NEFM
Neurofilament medium polypeptide

Protein Summary
Description
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221166
  • ENSP00000221166
  • ENSG00000104722
  • ENST00000433454
  • ENSP00000412295

Symbol
  • NEF3
  • NFM
  • NFM
  • NEF3
  • NF-M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.96
PubMedID
0.77
protein domain
0.73
cell type or tissue
0.68
chemical
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 393.4   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 638   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 393.4   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 638   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
DES
Tbio
Novelty:  0.00651741
p_int:  0.99999986
p_ni:  2e-8
p_wrong:  1.2e-7
Score:  0.829
Data Source:  BioPlex,STRINGDB
INA
Tbio
Novelty:  0.00708581
p_int:  0.999999748
p_ni:  2.52e-7
Score:  0.83
Data Source:  BioPlex,STRINGDB
VIM
Tbio
Novelty:  0.00030317
p_int:  0.999999746
p_ni:  2.54e-7
Score:  0.83
Data Source:  BioPlex,STRINGDB
NEFL
Tbio
Novelty:  0.00049255
p_int:  0.999997053
p_ni:  0.000002947
Score:  0.968
Data Source:  BioPlex,STRINGDB
NES
Tbio
Novelty:  0.00035379
p_int:  0.999996297
p_ni:  0.000003703
Score:  0.864
Data Source:  BioPlex,STRINGDB
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.999985282
p_ni:  0.000014718
Score:  0.667
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.999977453
p_ni:  0.000022547
Data Source:  BioPlex
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.999790068
p_ni:  0.000209932
Data Source:  BioPlex
LURAP1L
Tdark
Novelty:  2.32630524
p_int:  0.999717334
p_ni:  0.000282666
Score:  0.211
Data Source:  BioPlex,STRINGDB
FBXW5
Tbio
Novelty:  0.13100873
p_int:  0.999444293
p_ni:  0.000555699
p_wrong:  8e-9
Data Source:  BioPlex
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pallidum volume
1
1
0
6.7
8.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pallidum volume
0
6.7
8.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurofilament medium
VGNC:14574
745196
Macaque
neurofilament medium
711196
Mouse
MGI:97314
18040
Rat
RGD:3160
24588
Dog
neurofilament medium
VGNC:43725
486111
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurofilament medium
Macaque
neurofilament medium
Mouse
Rat
Dog
neurofilament medium
Publication Statistics
PubMed Score 393.40
PubMed score by year
PubTator Score 138.04
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title