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Tchem
NEDD8
NEDD8

Protein Summary
Description
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250495
  • ENSP00000250495
  • ENSG00000129559
  • ENST00000643069
  • ENSP00000496420
  • ENSG00000285246

Symbol
  • NEDD-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
0.99
kinase perturbation
0.96
interacting protein
0.91
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 343.6   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 447   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 343.6   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 447   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (615)
UBE2M
Tchem
Novelty:  0.02353106
p_int:  0.840053525
p_ni:  0.159946475
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.789902863
p_ni:  0.210097137
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.999
Data Source:  Reactome,STRINGDB
UBA3
Tchem
Novelty:  0.03962261
Score:  0.999
Data Source:  Reactome,STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.999
Data Source:  Reactome,STRINGDB
DCUN1D1
Tchem
Novelty:  0.03122408
Score:  0.999
Data Source:  Reactome,STRINGDB
SENP8
Tchem
Family:  Enzyme
Novelty:  0.00774396
Score:  0.999
Data Source:  Reactome,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.997
Data Source:  Reactome,STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.996
Data Source:  STRINGDB
NAE1
Tchem
Novelty:  0.0283623
Score:  0.996
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Deubiquitination
Reactome
Iron uptake and transport
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Deubiquitination
Iron uptake and transport
Membrane Trafficking
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
82.9
telomere length
1
1
1
82.9
platelet count
2
2
2
75
platelet count
2
2
2
75
mean corpuscular volume
2
2
2
62
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
82.9
telomere length
1
82.9
platelet count
2
75
platelet count
2
75
mean corpuscular volume
2
62
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
magnesium dependent phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:28781]
Mouse
MGI:97301
18002
Rat
RGD:3158
25490
Dog
neural precursor cell expressed, developmentally down-regulated 8
480265
Horse
neural precursor cell expressed, developmentally down-regulated 8
100051307
Species
Name
OMA
EggNOG
Inparanoid
Macaque
magnesium dependent phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:28781]
Mouse
Rat
Dog
neural precursor cell expressed, developmentally down-regulated 8
Horse
neural precursor cell expressed, developmentally down-regulated 8
Publication Statistics
PubMed Score 343.60
PubMed score by year
PubTator Score 256.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title