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Tbio
NEDD4L
E3 ubiquitin-protein ligase NEDD4-like

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). This gene encodes a member of the Nedd4 family ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256830
  • ENSP00000256830
  • ENSG00000049759
  • ENST00000356462
  • ENSP00000348847
  • ENST00000357895
  • ENSP00000350569
  • ENST00000382850
  • ENSP00000372301
  • ENST00000400345
  • ENSP00000383199
  • ENST00000431212
  • ENSP00000389406
  • ENST00000435432
  • ENSP00000393395
  • ENST00000456173
  • ENSP00000405440
  • ENST00000456986
  • ENSP00000411947
  • ENST00000586263
  • ENSP00000468546

Symbol
  • KIAA0439
  • NEDL3
  • RSP5
  • PVNH7
  • NEDD4-2
  • NEDD4.2
  • hNEDD4-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
transcription factor perturbation
0.98
transcription factor binding site profile
0.92
virus perturbation
0.92
transcription factor
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 514.39   (req: < 5)
Gene RIFs: 105   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 514.39   (req: >= 5)
Gene RIFs: 105   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0