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Tclin
NECTIN4
Nectin-4

Protein Summary
Description
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus. This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368012
  • ENSP00000356991
  • ENSG00000143217

Symbol
  • LNIR
  • PRR4
  • PVRL4
  • LNIR
  • PRR4
  • EDSS1
  • PVRL4
  • nectin-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.54   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.54   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
PDSS1
Tbio
Family:  Enzyme
Novelty:  0.01542427
p_int:  0.999995159
p_ni:  0.000004825
p_wrong:  1.6e-8
Score:  0.224
Data Source:  BioPlex,STRINGDB
TMEM173
Tchem
Novelty:  0.0070581
p_int:  0.999991947
p_ni:  0.000008053
Score:  0.403
Data Source:  BioPlex,STRINGDB
C6orf62
Tdark
Novelty:  1.21509188
p_int:  0.999990105
p_ni:  7.6e-8
p_wrong:  0.000009819
Score:  0.403
Data Source:  BioPlex,STRINGDB
FBXO10
Tbio
Novelty:  0.18324932
p_int:  0.999902062
p_ni:  0.000097938
Score:  0.243
Data Source:  BioPlex,STRINGDB
ZNF582
Tbio
Family:  TF
Novelty:  0.09450649
p_int:  0.999374056
p_ni:  0.000625943
p_wrong:  1e-9
Score:  0.403
Data Source:  BioPlex,STRINGDB
ENAH
Tbio
Novelty:  0.02329247
p_int:  0.996997003
p_ni:  0.003002997
Score:  0.656
Data Source:  BioPlex,STRINGDB
EIF2B3
Tbio
Novelty:  0.04963646
p_int:  0.996591015
p_ni:  0.003408985
Score:  0.596
Data Source:  BioPlex,STRINGDB
EVL
Tbio
Novelty:  0.03533257
p_int:  0.982908282
p_ni:  0.017091718
Score:  0.237
Data Source:  BioPlex,STRINGDB
EIF2B2
Tbio
Novelty:  0.03253919
p_int:  0.974551062
p_ni:  0.025448938
Data Source:  BioPlex
EIF2B4
Tbio
Novelty:  0.05080792
p_int:  0.967940715
p_ni:  0.032059285
Data Source:  BioPlex
Pathways (6)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Nectin/Necl trans heterodimerization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Nectin/Necl trans heterodimerization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
3
85.2
monocyte count
1
1
1
77.7
leukocyte count
1
1
1
75.7
1
1
0
1.1
63.4
serum non-albumin protein measurement
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
3
85.2
monocyte count
1
77.7
leukocyte count
1
75.7
0
1.1
63.4
serum non-albumin protein measurement
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nectin cell adhesion molecule 4
VGNC:8080
100610618
Mouse
MGI:1918990
71740
Rat
RGD:1559826
498281
Dog
nectin cell adhesion molecule 4
VGNC:43719
609931
Horse
nectin cell adhesion molecule 4
VGNC:20657
100066309
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nectin cell adhesion molecule 4
Mouse
Rat
Dog
nectin cell adhesion molecule 4
Horse
nectin cell adhesion molecule 4
Publication Statistics
PubMed Score 174.54
PubMed score by year
PubTator Score 95.66
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title