Protein Summary
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus. This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not ...more
- ENST00000368012
- ENSP00000356991
- ENSG00000143217
- LNIR
- PRR4
- PVRL4
- LNIR
- PRR4
- EDSS1
- PVRL4
- nectin-4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 174.54 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 216 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 174.54 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 216 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (32)
PDSS1
Family: Enzyme
Novelty: 0.01542427
p_int: 0.999995159
p_ni: 0.000004825
p_wrong: 1.6e-8
Score: 0.224
Data Source: BioPlex,STRINGDB
TMEM173
Novelty: 0.0070581
p_int: 0.999991947
p_ni: 0.000008053
Score: 0.403
Data Source: BioPlex,STRINGDB
C6orf62
Novelty: 1.21509188
p_int: 0.999990105
p_ni: 7.6e-8
p_wrong: 0.000009819
Score: 0.403
Data Source: BioPlex,STRINGDB
FBXO10
Novelty: 0.18324932
p_int: 0.999902062
p_ni: 0.000097938
Score: 0.243
Data Source: BioPlex,STRINGDB
ZNF582
Family: TF
Novelty: 0.09450649
p_int: 0.999374056
p_ni: 0.000625943
p_wrong: 1e-9
Score: 0.403
Data Source: BioPlex,STRINGDB
ENAH
Novelty: 0.02329247
p_int: 0.996997003
p_ni: 0.003002997
Score: 0.656
Data Source: BioPlex,STRINGDB
EIF2B3
Novelty: 0.04963646
p_int: 0.996591015
p_ni: 0.003408985
Score: 0.596
Data Source: BioPlex,STRINGDB
EVL
Novelty: 0.03533257
p_int: 0.982908282
p_ni: 0.017091718
Score: 0.237
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (6)
Reactome (5)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adherens junctions interactions | ||||
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Nectin/Necl trans heterodimerization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adherens junctions interactions | ||||
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Nectin/Necl trans heterodimerization | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (5)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 2 | 3 | 85.2 | |||||
monocyte count | 1 | 1 | 1 | 77.7 | |||||
leukocyte count | 1 | 1 | 1 | 75.7 | |||||
1 | 1 | 0 | 1.1 | 63.4 | |||||
serum non-albumin protein measurement | 1 | 1 | 1 | 49.5 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 3 | 85.2 | |||||
monocyte count | 1 | 77.7 | |||||
leukocyte count | 1 | 75.7 | |||||
0 | 1.1 | 63.4 | |||||
serum non-albumin protein measurement | 1 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | nectin cell adhesion molecule 4 | VGNC:8080 | 100610618 | |||||
Mouse | MGI:1918990 | 71740 | ||||||
Rat | RGD:1559826 | 498281 | ||||||
Dog | nectin cell adhesion molecule 4 | VGNC:43719 | 609931 | |||||
Horse | nectin cell adhesion molecule 4 | VGNC:20657 | 100066309 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | nectin cell adhesion molecule 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nectin cell adhesion molecule 4 | |||||
Horse | nectin cell adhesion molecule 4 | |||||
Publication Statistics
PubMed Score 174.54
PubMed score by year
PubTator Score 95.66
PubTator score by year
Related Publications
Text Mined References (49)
GeneRif Annotations (36)
Items per page:
0 of 0
PMID | Year | Title |
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