Tclin NECTIN4 Nectin-4

Protein Summary

Description

Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus. This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q96NY8
• B4DQW3
• Q96K15

Gene Name

• NECTIN4

Ensembl ID

• ENST00000368012
• ENSP00000356991
• ENSG00000143217

Symbol

• LNIR
• PRR4
• PVRL4
• LNIR
• PRR4
• EDSS1
• PVRL4
• nectin-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.54   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 216   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.54   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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1 – 1 of 1

enfortumab vedotin

NECTIN4Tclin

BINDING AGENT pKi : 10.24

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (32)

Explore Interacting Targets

1 – 10 of 32

• See Interactions on String-DB

PDSS1

Tbio

Family:  Enzyme

Novelty:  0.01542427

p_int:  0.999995159

p_ni:  0.000004825

p_wrong:  1.6e-8

Score:  0.224

Data Source:  BioPlex,STRINGDB

TMEM173

Tchem

Novelty:  0.0070581

p_int:  0.999991947

p_ni:  0.000008053

Score:  0.403

Data Source:  BioPlex,STRINGDB

C6orf62

Tdark

Novelty:  1.21509188

p_int:  0.999990105

p_ni:  7.6e-8

p_wrong:  0.000009819

Score:  0.403

Data Source:  BioPlex,STRINGDB

FBXO10

Tbio

Novelty:  0.18324932

p_int:  0.999902062

p_ni:  0.000097938

Score:  0.243

Data Source:  BioPlex,STRINGDB

ZNF582

Tbio

Family:  TF

Novelty:  0.09450649

p_int:  0.999374056

p_ni:  0.000625943

p_wrong:  1e-9

Score:  0.403

Data Source:  BioPlex,STRINGDB

ENAH

Tbio

Novelty:  0.02329247

p_int:  0.996997003

p_ni:  0.003002997

Score:  0.656

Data Source:  BioPlex,STRINGDB

EIF2B3

Tbio

Novelty:  0.04963646

p_int:  0.996591015

p_ni:  0.003408985

Score:  0.596

Data Source:  BioPlex,STRINGDB

EVL

Tbio

Novelty:  0.03533257

p_int:  0.982908282

p_ni:  0.017091718

Score:  0.237

Data Source:  BioPlex,STRINGDB

EIF2B2

Tbio

Novelty:  0.03253919

p_int:  0.974551062

p_ni:  0.025448938

Data Source:  BioPlex

EIF2B4

Tbio

Novelty:  0.05080792

p_int:  0.967940715

p_ni:  0.032059285

Data Source:  BioPlex

Nearest Tclin Targets (2)

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Upstream (1)

Downstream (1)

1 – 1 of 1

SRC

Tclin

Family:  Kinase

KEGG Distance:  4

Common Pathways:  1

1: Adherens junction

Pathways (6)

Reactome (5)

KEGG (1)

Adherens junctions interactions (R-HSA-418990)

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Find Similar Targets

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adherens junctions interactions	31 targets	R-HSA-418990
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-cell junction organization	63 targets	R-HSA-421270
Reactome	Nectin/Necl trans heterodimerization	7 targets	R-HSA-420597

Name	Explore in Pharos	Explore in Source
Adherens junctions interactions	31 targets	R-HSA-418990
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-cell junction organization	63 targets	R-HSA-421270
Nectin/Necl trans heterodimerization	7 targets	R-HSA-420597

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (5)

Components (5)

Processes (3)

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10

1 – 5 of 5

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
cell adhesion molecule binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein homodimerization activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
signaling receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
virus receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (10)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	2	2	3		85.2
monocyte count	EFO_0005091	1	1	1		77.7
leukocyte count	EFO_0004308	1	1	1		75.7
asthma	EFO_0000270	1	1	0	1.1	63.4
serum non-albumin protein measurement	EFO_0004568	1	1	1		49.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	3		85.2
monocyte count	EFO_0005091	1		77.7
leukocyte count	EFO_0004308	1		75.7
asthma	EFO_0000270	0	1.1	63.4
serum non-albumin protein measurement	EFO_0004568	1		49.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell adhesion
Cell junction
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Ectodermal dysplasia
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
Alzheimer's disease
asthma
blood protein measurement
family history of Alzheimer’s disease
granulocyte percentage of myeloid white cells
leukocyte count
mathematical ability
monocyte count
monocyte percentage of leukocytes
serum non-albumin protein measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nectin cell adhesion molecule 4	VGNC:8080	100610618
Mouse	nectin cell adhesion molecule 4	MGI:1918990	71740
Rat	nectin cell adhesion molecule 4	RGD:1559826	498281
Dog	nectin cell adhesion molecule 4	VGNC:43719	609931
Horse	nectin cell adhesion molecule 4	VGNC:20657	100066309

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nectin cell adhesion molecule 4
Mouse	nectin cell adhesion molecule 4
Rat	nectin cell adhesion molecule 4
Dog	nectin cell adhesion molecule 4
Horse	nectin cell adhesion molecule 4

Publication Statistics

PubMed Score 174.54

PubMed score by year

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PubTator Score 95.66

PubTator score by year

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Related Publications

Text Mined References (49)

GeneRif Annotations (36)

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10

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PMID	Year	Title