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Tbio
NECTIN3
Nectin-3

Protein Summary
Description
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319792
  • ENSP00000321514
  • ENSG00000177707
  • ENST00000485303
  • ENSP00000418070
  • ENST00000493615
  • ENSP00000420579

Symbol
  • PRR3
  • PVRL3
  • PPR3
  • PRR3
  • CD113
  • PVRL3
  • PVRR3
  • CDW113
  • NECTIN-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.23   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.23   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.999954501
p_ni:  0.000020557
p_wrong:  0.000024943
Data Source:  BioPlex
NECTIN1
Tbio
Novelty:  0.00348549
p_int:  0.99983781
p_ni:  3e-9
p_wrong:  0.000162186
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
NPTX1
Tbio
Novelty:  0.02872516
p_int:  0.999802626
p_ni:  0.000197374
Score:  0.154
Data Source:  BioPlex,STRINGDB
HFE
Tbio
Novelty:  0.00042077
p_int:  0.998961812
p_ni:  0.001013807
p_wrong:  0.000024381
Data Source:  BioPlex
MAK
Tchem
Family:  Kinase
Novelty:  0.04630863
p_int:  0.997773794
p_ni:  2.61e-7
p_wrong:  0.002225944
Score:  0.527
Data Source:  BioPlex,STRINGDB
NECTIN2
Tbio
Novelty:  0.00910836
p_int:  0.99437014
p_ni:  0.00562986
Score:  0.969
Data Source:  BioPlex,Reactome,STRINGDB
ASPH
Tbio
Family:  Enzyme
Novelty:  0.00291455
p_int:  0.962793815
p_ni:  0.037206185
Score:  0.194
Data Source:  BioPlex,STRINGDB
FBXO2
Tbio
Novelty:  0.01578361
p_int:  0.885449872
p_ni:  0.114489407
p_wrong:  0.000060721
Score:  0.571
Data Source:  BioPlex,STRINGDB
ERO1B
Tbio
Novelty:  0.06389159
p_int:  0.856413822
p_ni:  0.143586173
p_wrong:  5e-9
Score:  0.665
Data Source:  BioPlex,STRINGDB
COL14A1
Tbio
Novelty:  0.01760399
p_int:  0.850661751
p_ni:  0.149338249
Data Source:  BioPlex
Pathways (8)
Adherens junctions interactions (R-HSA-418990)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Nectin/Necl trans heterodimerization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Nectin/Necl trans heterodimerization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
HGNC
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
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IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1930171
58998
Horse
nectin cell adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:17664]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
nectin cell adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:17664]
Publication Statistics
PubMed Score 76.23
PubMed score by year
PubTator Score 27.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title