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Tbio
NECTIN1
Nectin-1

Protein Summary
Description
Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity. (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV. This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264025
  • ENSP00000264025
  • ENSG00000110400
  • ENST00000340882
  • ENSP00000345289
  • ENST00000341398
  • ENSP00000344974

Symbol
  • HVEC
  • PRR1
  • PVRL1
  • ED4
  • PRR
  • HIgR
  • HV1S
  • HVEC
  • OFC7
  • PRR1
  • PVRR
  • CD111
  • PVRL1
  • PVRR1
  • SK-12
  • CLPED1
  • nectin-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.21   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.21   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
NECTIN3
Tbio
Novelty:  0.01288113
p_int:  0.99983781
p_ni:  3e-9
p_wrong:  0.000162186
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.997569148
p_ni:  0.000001679
p_wrong:  0.002429173
Score:  0.278
Data Source:  BioPlex,STRINGDB
AFDN
Tbio
Novelty:  0.00372947
Score:  0.979
Data Source:  Reactome,STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.966
Data Source:  STRINGDB
NECTIN4
Tclin
Novelty:  0.00694563
Score:  0.946
Data Source:  Reactome,STRINGDB
PVR
Tbio
Novelty:  0.00215811
Score:  0.943
Data Source:  STRINGDB
NECTIN2
Tbio
Novelty:  0.00910836
Score:  0.923
Data Source:  Reactome,STRINGDB
CADM3
Tbio
Novelty:  0.01907524
Score:  0.921
Data Source:  Reactome,STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.92
Data Source:  STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
Score:  0.918
Data Source:  STRINGDB
Pathways (11)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Nectin/Necl trans heterodimerization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Nectin/Necl trans heterodimerization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
HGNC
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
5
55.3
sex hormone-binding globulin measurement
1
1
1
1.8
cognitive function measurement
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
5
55.3
sex hormone-binding globulin measurement
1
1.8
cognitive function measurement
1
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nectin cell adhesion molecule 1
VGNC:53071
745188
Mouse
MGI:1926483
58235
Rat
RGD:620791
192183
Dog
nectin cell adhesion molecule 1
VGNC:43718
489363
Horse
nectin cell adhesion molecule 1
VGNC:20656
100063411
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nectin cell adhesion molecule 1
Mouse
Rat
Dog
nectin cell adhesion molecule 1
Horse
nectin cell adhesion molecule 1
Publication Statistics
PubMed Score 424.21
PubMed score by year
PubTator Score 192.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title