Tdark NECAP2 Adaptin ear-binding coat-associated protein 2

Protein Summary

Description

Involved in endocytosis. This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q9NVZ3
• B4DY19
• E9PGQ8
• Q5VSU4
• Q5VSU5
• Q9H7L1
• Q9H8L1

Gene Name

• NECAP2

Ensembl ID

• ENST00000337132
• ENSP00000338746
• ENSG00000157191
• ENST00000443980
• ENSP00000391942
• ENST00000457722
• ENSP00000407091
• ENST00000492095
• ENSP00000427620

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
virus perturbation	0.83
kinase perturbation	0.81
transcription factor binding site profile	0.73
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Adaptin Ear-binding Coat-associated Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.56   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.56   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (202)

Explore Interacting Targets

1 – 10 of 202

• See Interactions on String-DB

AP2M1

Tbio

Novelty:  0.00769368

p_int:  0.999999999

p_ni:  1e-9

Score:  0.959

Data Source:  BioPlex,STRINGDB

AP2S1

Tbio

Novelty:  0.01931502

p_int:  0.999999347

p_ni:  6.53e-7

Score:  0.983

Data Source:  BioPlex,STRINGDB

AP2A2

Tbio

Novelty:  0.08851191

p_int:  0.999998885

p_ni:  0.000001115

Score:  0.978

Data Source:  BioPlex,STRINGDB

AP1B1

Tbio

Novelty:  0.03370208

p_int:  0.999993696

p_ni:  0.000006304

Score:  0.753

Data Source:  BioPlex,STRINGDB

AP2A1

Tbio

Novelty:  0.08554974

p_int:  0.999981008

p_ni:  0.000018992

Score:  0.992

Data Source:  BioPlex,STRINGDB

NECAP1

Tbio

Novelty:  0.13047417

p_int:  0.99987652

p_ni:  0.000107227

p_wrong:  0.000016253

Score:  0.985

Data Source:  BioPlex,STRINGDB

EVA1B

Tdark

Novelty:  2.1380272

p_int:  0.999830194

p_ni:  0.000157732

p_wrong:  0.000012074

Data Source:  BioPlex

RUNDC3A

Tdark

Novelty:  0.23296904

p_int:  0.999534879

p_ni:  0.00046512

p_wrong:  1e-9

Score:  0.81

Data Source:  BioPlex,STRINGDB

SPATA1

Tdark

p_int:  0.999499194

p_ni:  0.000500802

p_wrong:  4e-9

Data Source:  BioPlex

AP2B1

Tbio

Novelty:  0.00921093

p_int:  0.996686652

p_ni:  0.003313348

Score:  0.983

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (4)

Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Membrane Trafficking	612 targets	R-HSA-199991
Vesicle-mediated transport	725 targets	R-HSA-5653656

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Components (4)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
intracellular	Inferred from Direct Assay (IDA)	LIFEdb
clathrin vesicle coat	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
clathrin-coated pit	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
plasma membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	1	2	2		80.5
body height	EFO_0004339	1	1	1		8.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	2		80.5
body height	EFO_0004339	1		8.7

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Cytoplasmic vesicle
Endocytosis
Membrane
Phosphoprotein
Polymorphism
Protein transport
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
body height
serum gamma-glutamyl transferase measurement

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NECAP endocytosis associated 2	VGNC:1345	456477
Macaque	NECAP endocytosis associated 2		698687
Mouse	NECAP endocytosis associated 2	MGI:1913397	66147
Rat	NECAP endocytosis associated 2	RGD:735063	298598
Dog	NECAP endocytosis associated 2	VGNC:43717	478218

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NECAP endocytosis associated 2
Macaque	NECAP endocytosis associated 2
Mouse	NECAP endocytosis associated 2
Rat	NECAP endocytosis associated 2
Dog	NECAP endocytosis associated 2

Publication Statistics

PubMed Score 2.56

PubMed score by year

Reset Zoom

PubTator Score 2.66

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (16)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title