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Tdark
NECAP2
Adaptin ear-binding coat-associated protein 2

Protein Summary
Description
Involved in endocytosis. This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337132
  • ENSP00000338746
  • ENSG00000157191
  • ENST00000443980
  • ENSP00000391942
  • ENST00000457722
  • ENSP00000407091
  • ENST00000492095
  • ENSP00000427620
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
virus perturbation
0.83
kinase perturbation
0.81
transcription factor binding site profile
0.73
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.56   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.56   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (202)
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999999999
p_ni:  1e-9
Score:  0.959
Data Source:  BioPlex,STRINGDB
AP2S1
Tbio
Novelty:  0.01931502
p_int:  0.999999347
p_ni:  6.53e-7
Score:  0.983
Data Source:  BioPlex,STRINGDB
AP2A2
Tbio
Novelty:  0.08851191
p_int:  0.999998885
p_ni:  0.000001115
Score:  0.978
Data Source:  BioPlex,STRINGDB
AP1B1
Tbio
Novelty:  0.03370208
p_int:  0.999993696
p_ni:  0.000006304
Score:  0.753
Data Source:  BioPlex,STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
p_int:  0.999981008
p_ni:  0.000018992
Score:  0.992
Data Source:  BioPlex,STRINGDB
NECAP1
Tbio
Novelty:  0.13047417
p_int:  0.99987652
p_ni:  0.000107227
p_wrong:  0.000016253
Score:  0.985
Data Source:  BioPlex,STRINGDB
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.999830194
p_ni:  0.000157732
p_wrong:  0.000012074
Data Source:  BioPlex
RUNDC3A
Tdark
Novelty:  0.23296904
p_int:  0.999534879
p_ni:  0.00046512
p_wrong:  1e-9
Score:  0.81
Data Source:  BioPlex,STRINGDB
SPATA1
Tdark
p_int:  0.999499194
p_ni:  0.000500802
p_wrong:  4e-9
Data Source:  BioPlex
AP2B1
Tbio
Novelty:  0.00921093
p_int:  0.996686652
p_ni:  0.003313348
Score:  0.983
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
2
2
80.5
body height
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
80.5
body height
1
8.7
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NECAP endocytosis associated 2
VGNC:1345
456477
Macaque
NECAP endocytosis associated 2
698687
Mouse
MGI:1913397
66147
Rat
RGD:735063
298598
Dog
NECAP endocytosis associated 2
VGNC:43717
478218
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NECAP endocytosis associated 2
Macaque
NECAP endocytosis associated 2
Mouse
Rat
Dog
NECAP endocytosis associated 2
Publication Statistics
PubMed Score 2.56
PubMed score by year
PubTator Score 2.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title