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Tbio
NEBL
Nebulette

Protein Summary
Description
Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623). Isoform 2 might play a role in the assembly of focal adhesion (PubMed:15004028). This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377122
  • ENSP00000366326
  • ENSG00000078114
  • ENST00000417816
  • ENSP00000393896

Symbol
  • LNEBL
  • LASP2
  • LNEBL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
PubMedID
0.97
transcription factor perturbation
0.91
small molecule perturbation
0.75
histone modification site profile
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.26   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.26   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
ZNF764
Tdark
Family:  TF
Novelty:  0.76308829
p_int:  1
Score:  0.161
Data Source:  BioPlex,STRINGDB
FAM19A5
Tdark
Novelty:  0.07792418
p_int:  0.999899698
p_ni:  2e-9
p_wrong:  0.0001003
Data Source:  BioPlex
GCHFR
Tbio
Family:  Enzyme
Novelty:  0.04287433
p_int:  0.995172667
p_ni:  0.000050297
p_wrong:  0.004777037
Score:  0.219
Data Source:  BioPlex,STRINGDB
DHX38
Tbio
Family:  Enzyme
Novelty:  0.01939445
p_int:  0.953002458
p_ni:  0.037753168
p_wrong:  0.009244374
Score:  0.219
Data Source:  BioPlex,STRINGDB
NAXD
Tbio
Family:  Enzyme
Novelty:  0.07681941
p_int:  0.777512839
p_ni:  0.222448992
p_wrong:  0.000038169
Score:  0.219
Data Source:  BioPlex,STRINGDB
MYPN
Tbio
Novelty:  0.03041873
Score:  0.817
Data Source:  STRINGDB
HAND2
Tbio
Family:  TF
Novelty:  0.00478924
Score:  0.745
Data Source:  STRINGDB
DAZAP1
Tbio
Novelty:  0.04307077
Score:  0.719
Data Source:  STRINGDB
TTN
Tbio
Family:  Kinase
Novelty:  0.00040356
Score:  0.683
Data Source:  STRINGDB
ZYX
Tbio
Novelty:  0.00375452
Score:  0.672
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
62.8
1
1
0
1.2
61.4
cup-to-disc ratio measurement
1
1
1
51.4
mathematical ability
2
2
2
41.9
1
1
0
32.2
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
62.8
0
1.2
61.4
cup-to-disc ratio measurement
1
51.4
mathematical ability
2
41.9
0
32.2
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nebulette
702764
Dog
nebulette
VGNC:43713
477974
Cow
nebulette
517987
Pig
nebulette
100522395
Opossum
nebulette
100019946
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nebulette
Dog
nebulette
Cow
nebulette
Pig
nebulette
Opossum
nebulette
Publication Statistics
PubMed Score 53.26
PubMed score by year
PubTator Score 18.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title